摘要
目的探讨慢性肝病血小板生成减少的机制。方法ELISA双抗夹心法测定正常人群及慢性肝病患者的血小板生成素水平(Tpo)水平。结果(1)肝病患者Tpo>143组与Tpo>143组总胆固醇(CHOL)水平比较有显著性差异(P<0.05);其他生化指标无显著性差异。(2)肝病患者血小板正常组(38例)与减少组(37例)Tpo水平比较有显著性差异,[(144.76±108.93)vs(100.19±66.43)pg/ml,P<0.05]。但Tpo水平与血小板计数不相关,(r=0.175,P>0.05)。结论慢性肝病患者肝脏的合成功能下降导致Tpo水平的降低,而Tpo水平降低是血小板减少的一个重要原因。
Objective To study the mechanism of decrease production of platelet in patients with liver diseases. Methods Serum thrombepoietin levels was detected in patients with liver diseases and healthy controis with ELISA method. Results The Liver Function marker except total cholesterol（T-CHOL） were no significane in liver disease, patients with Tpn levels below 143 pg/ml （54 patients） and above 143 pg/ml （21 patients）; Patients（38 patients） with normal platelet counts showed higher Tpo levels than those（37 patients） with low platelet counts[（144.76±108.93）vs（100.19±66.43） pg/ml, P〈0.05],but serum Tpo levels is not associated with platelet counts in liver disease, （r=0.175, P〉0.05）. Conclusions These findings suggested Tpo levels of patients might be one of the masons of thrembecytnpenia with liver disease, The decrease of Tpo levels may be related to compound of Liver Function.
出处
《海南医学》
CAS
2006年第2期126-127,共2页
Hainan Medical Journal
关键词
肝病
血小板生成素
肝功能
血小板
Liver Diseases
Thrembopoietin
Liver Function
Platelet
