摘要
目的探讨小儿巨细胞病毒(CMV)相关性下呼吸道感染(LRI)的临床特点及治疗方法。方法对38例经ELISA法检测诊断为小儿CMV相关性LRI患儿的临床及治疗进行分析。结果38例患儿中,小于1岁34例(占89.5%),母乳喂养+混合喂养29例(占76.3%),临床以咳嗽、喘息、发热、呼吸困难为主要表现,肺部体征及X线改变明显,外周血象WBC升高22例(占57.9%),分类多正常,Hb下降12例(占31.6%),合并其他感染13例(占34.2%),肺外脏器受损21例(占55.3%),入院前均未明确病原;经更昔洛韦(GCV)治疗,痊愈30例(78.9%),好转6例,死亡2例(5.3%)。结论小儿CMV相关性LRI多发生在以母乳或混合喂养的婴儿,其临床症状、体征、X线及外周血象缺乏特异性,常合并其他病原体感染和肺外脏器受损,易误诊误治;更昔洛韦治疗安全、有效,病情严重者可出现死亡。
Objective To investigate the Clinical feature, and treatment of Cytomegalovirus（CMV）-asseciated low respiratory tract infection （LRI） in childhood. Methods The Clinical data of 38 patients diagnosed as CMV-asseciated LRI determined by ELISA were analyzed. Results 34 of 38 cases （89.5%） were less than 1 year, hreast-feefling and mixed-leo：ling 29 cases（76.3%）. The clinical symptoms chiefly included cough, wheel, fever, dyspnea, body signs and X-ray changes of lung are obvious, WBC of blood routine increased in 22 cases （57.9%）, most differential counts were normal, Hb of 12 cases（31.6%） descend, 13 cases（34.2%d） were accompanied by other infections, damages of out-of-lung organ had 21 cases （55.3%）, The pathogens of all patients were not certain before hospitalization; All patients were treated by Ganciclovir（GCV）, 30 cases（78.9%） recovered, 6 cases improved, 2 cases（5.3%） died. Conclusions CMV-associated LRI usually takes place in infant feeded with breast or mixed feeding, its clinical symptoms, body signs, X-ray and blood routine are not specifteal. This disease often aecompanys other infections and out-of-lung damages, often oecum errenoous diagnosis and treatment; The treatment of GCV is safe, efficient. Severe cases can result in death.
出处
《海南医学》
CAS
2006年第2期37-39,共3页
Hainan Medical Journal
关键词
下呼吸道
巨细胞病毒
感染
更昔洛韦
low respiratory tract
Cytomegalovirus infection
Ganciclovir
