摘要
目的通过定量分析良性前列腺增生(BPH)患者前列腺和成人正常前列腺移行带腺体各成分含量及相关组织学形态的变化,探讨良性前列腺增生症治疗方案的选择。方法用计算机图像分析系统对经HE染色的40例良性前列腺增生症患者手术切除的前列腺和10例成人正常前列腺移行带组织标本进行形态学定量分析,分别测定腺体、腺腔、上皮的平均面积及上皮细胞高度。结果(1)正常前列腺和BPH前列腺移行带上皮细胞高度分别为(24.87±4.53)μm和(19.06±5.49)μm(P<0.001)。(2)正常前列腺和BPH前列腺移行带腺体、上皮、腺腔的平均面积分别为(0.087±0.028)mm2和(0.062±0.030)mm2(P<0.01)、(0.042±0.016)mm2和(0.027±0.013)mm2(P<0.01)、(0.045±0.018)mm2和(0.035±0.021)mm2(P>0.05)。结论BPH前列腺组织主要以基质成分增生为主;BPH的治疗应以α受体阻滞剂和手术治疗为主。
Objective To evaluate quantitatively the acinar components and relative morphological changes of the transition zone in various prostates, Methods The quantitative morphometry of forty BPH specimens obtained from suprapubic transvesical prostatectomy and ten normal prostatic specimens was performed with computer-assisted image analysis system, and all samples were stained with haematoxylin and eosin （HE）. The mean epithelial heights and the average areas of acini, lumens and epithelial cells were quantitated respectively. Results 1, The epithelial heights of adult normal prostate and hyperplastic prostate were （24.87±4.53） μm and （19.06±5.49） μm （P〈0.001）. 2. The average areas of acinus, epithelium and lumen of the normal control transition zone tissue and BPH group were （0.087±0.028）mm^2 and （0.062±0.030）mm^2（P〈0.01）, （0.042±0.016）mm^2 and （0.027±0.013）mm^2 （P〈0.01）, （0.045±0.018）mm^2 and （0.035±0.021） mm^2 （P〈0.05）, respectively. Conclusion Stroma is the most proliferative component in the prostatic tissue of BPH, Alpha receptor blockade and surgical therapy should be considered firstly in treatment of BPH.
出处
《中国男科学杂志》
CAS
CSCD
2006年第1期25-27,共3页
Chinese Journal of Andrology
关键词
前列腺
前列腺增生
图像处理
计算机辅助
prostate
prostatic hyperplasia
image processing, computer-assisted
