摘要
目的:观察肠炎康对溃疡性结肠炎动物的功效和作用机理。方法:采用三硝基苯磺酸法制备大鼠实验性溃疡性结肠炎模型,观察各组结肠病理损伤,IL-1B、TNF-a、SOD、MDA等指标的变化;并观察肠炎康对小肠推进运动、炎症和疼痛的影响。结果:肠炎康能减轻溃疡性结肠炎的病理损伤;显著降低溃疡性结肠炎大鼠血清IL-1B、INF-a、结肠组织MDA含量,而提高SOD含量;能明显降低小肠内墨汁推进率,减慢小肠蠕动速度;能降低毛细血管的通透性,具有一定的抗炎作用;对化学因素引起的疼痛有较好的镇痛作用。结论:肠炎康有减轻结肠炎症损伤、减轻氧自由基的损害、解痉、抗炎镇痛的作用。
Objective： To investigate the effects and mechanism of Changyankang Decoction on chronic ulcerative colonitis. Methods. The rat ulcerative colonitis model was made with TNBS. The pathology of colon, IL-1B, TNF-a, SOD and MDA were measured in all groups, and the effect of the drug on movement of small intestine, inflammation and pain were observed. Results： The drug could alleviated pathologic damage of ulcer ative colonitis; debased IL - 1B, TNF - α in serum and MDA in colon, increased SOD in colon; depressed pushing rate of ink in small intestine, reduced penetration of capillary, resisted inflammation; lessened the pain arosed by chemicals. Conclusion. Changyankang decoction could alleviate pathologic damage and oxygen free radical damage to ulcerative colonitis, and it is effective to reduce intestine spasm, to resist inflammation and to lessen the pain.
出处
《现代预防医学》
CAS
北大核心
2006年第2期202-203,共2页
Modern Preventive Medicine
