摘要
目的探讨社区综合干预对新发生2型糖尿病患者胰岛功能的影响。方法通过社区糖尿病普查,将新发现的50例T2DM患者随机分为干预组27例和对照组23例,进行为期2年的社区综合干预和对照观察。观察中期和结束后,检测两组患者的血压、体重指数(BMI)、腰臀围比(WHR)、血糖(PG)、糖化血红蛋白(HBA1C)、血胰岛素(INS),利用HOMA模型中胰岛素抵抗指数(Homa-IR)、β细胞功能指数(Homa-β或HBCI)以及β细胞2h分泌功能指数(△I120/△G120)评价胰岛功能。结果干预组血压、WHR、BMI、2hINS、Homa-β与对照组比较差异无显著性;而干预组PG、HBA1C和Homa-IR则明显降低,对照组则升高;干预组△I120/△G120升高、对照组降低,P值分别是:0.01、0.000、0.015、0.014。结论社区综合干预可以改善新发生T2DM患者的胰岛功能。
Objective To investigate the effect of intervention on insular function of latest patients of type 2diabetes in community. Methods Fifty latest patients of type 2 diabetes were investigated two years and were randomly divided into two groups, There were 23 patients in control group, and 27patients in intervention group. Blood pressure, body mass index （BMI）, waist and hip line rate （WHR） ,plasma glucose and blood insulin levels were measured between and after intervention. HOMA model,insulin resistance index （Homa-IR）, beta- cell function index （Homa-β） or （HBCI） and β- cell secretive function index in 2 hours（ΔI120/ΔG120） were calculated. Results FBG, HBAIC, Homa -IR andΔI120/ΔG120 were significantly higher in intervention group than in control group （P 〈 0. 01） ,but there were no significant difference of systolic and diastolic blood pressure, WHR, BMI, 2hINS and Homa-β between two groups. Conclusions The insular function of latest patients of type 2 diabetes can be perfected by integrated intervention in community.
出处
《齐齐哈尔医学院学报》
2005年第12期1382-1383,共2页
Journal of Qiqihar Medical University
基金
安徽省淮北市科技局资助课题(No.012022)
