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糖基化低密度脂蛋白对血管内皮的损伤作用 被引量:1

Injury of Endothelial Cells Produced by Glycosylated Low Density Lipoprotein
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摘要 目的探讨糖基化低密度脂蛋白对血管内皮的实验性损伤作用。方法以体外非酶糖基化低密度脂蛋白与人脐静脉内皮细胞(EC)共同培养,以低密度脂蛋白(LDL)作对照,观察内皮细胞结构及功能的改变。结果糖化LDL250μg/ml可引起EC超微结构改变,增殖率减低(P<0.05)。培养上清液中血管紧张素转化酶(ACE)活性降低(P<0.05),VonWillbrandFactor(VWF)值升高(P<0.001),而糖化LDL125μg/ml、75μg/ml与LDL对EC的作用无差异。结论在体外,糖基化LDL250μg/ml可引起EC损伤,糖化LDL在体外对触发动脉粥样硬化的发生、发展有重大意义。 Objective To Observe the effects of glycosylated low density lipoprotein on endothelial cells,Methods Endothelial cells(Ecs) derived from human umbilical cord vein were cultured in vitro with GLDL(glycosylated low density lipoprotein) and LDL(low density lipoprotein)in different concentrations respectively.Results GLDL of 250 μg/ml could alter the ultrastructure of EC and reduce their proliferation. Also the activity of angiotensin converting enzyme(ACE) decreased and the level of Von Willibrand factor(VWF) increased in the supernatant significantly.However, GLDL of 125 μg/ml and 75μg/ml did not produce marked damage on EC compared with LDL.Conclusiong High level of GLDL can cause endothelial cells injury and change their function,thus accelerate atherosclerosis.
出处 《福建医学院学报》 1996年第2期122-125,共4页
基金 福建省卫生厅资助
关键词 糖基化 低密度脂蛋白 内皮细胞 糖尿病 冠心病 glycosylated low density lipoprotein endothelial cell atherosclerosis diabetes
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