摘要
目的探讨内皮素(ET)水平在慢性肾脏疾病发生、发展中所起的作用。方法采用放射免疫法对正常人和慢性肾脏疾病患者血浆、尿ET-1进行检测,同时测定其血肌酐(Scr)、尿β2-微球蛋白的值,计算肌酐清除率(Ccr)。结果各期慢性肾脏病患者血、尿ET-1、β2-MG均较正常人升高,差异有显著性意义(P<0.01)。β2-MG与Scr呈显著正相关(P<0.01),β2-MG与尿ET-1亦呈显著正相关(P<0.01)。血、尿ET-1均与Scr呈显著正相关(P<0.01),血ET-1与Ccr呈显著负相关(r=0.780,P<0.01),尿ET-1与Ccr呈显著负相关(r=0.888,P<0.01),且尿ET-1与Ccr相关性较血ET-1与Ccr相关性更强。结论尿ET-1与慢性肾脏病的发生、发展关系密切。
Objective To study the significance of the changes of plasm, urinary endothelin （ET） in the occurrence, development of chronic kidney disease. Methods The levels of plasm, urinary ET- 1 by radio-immuno-assay in patients with chronic kidney disease and the normal subjects, and Scr,uri- nary β2-MG,Ccr were also tested. Results The level of plasm, urinary ET-1 and urinary β2-MG were higher than that in the normal subjects （P d0.01）. β2-MG was significantly correlated with Scr（P〈 0.01）, β2-MG was also significantly correlated with urinary ET-1 （P 〈 0.01）. Plasm and urinary ET- 1 were both correlated with Scr （P〈 0.01）, Plasm ET-1 and Ccr had negative correlation（ r = 0. 780, P 〈 0.01）, Urinary ET-1 and Ccr had also negative correlation（ r = 0. 888, P 〈 0.01 ）. Conclusion The urinary ET-1 level is sensitive to reflect the renal function change and the progress of the renal impairment.
出处
《苏州大学学报（医学版）》
CAS
北大核心
2005年第6期1018-1019,1022,共3页
Suzhou University Journal of Medical Science
基金
苏州大学附属第一医院院内资助研究课题(No:H04009)
关键词
慢性肾脏病
内皮素
内生肌酐清除率
Β2-微球蛋白
chronic kidney disease
endothelin
endogenous creatinine clearance
β2-microglohulin
