摘要
目的探讨血脂及增龄对冠心病合并2型糖尿病患者冠状动脉造影特点的影响。方法在分析203例冠心病合并2型糖尿病患者冠状动脉造影特点的基础上,按年龄、血脂及年龄与血脂分组进行分析。结果203例患者冠状动脉造影多为多支病变(≥3支比<3支为59.1%比40.9%,P<0.01)且血管狭窄程度高(≥75%比<75%为66%比34%,P<0.001)。≥60岁组4支血管病变比例高于<60岁组,而≥60岁组单支血管病变比例低于<60岁组。并且≥60岁组左主干受累比例高于<60岁组;胆固醇异常组与胆固醇正常组相比,单支、双支、3支及4支血管病变、狭窄部位和狭窄程度的差异无统计学意义。年龄与血脂进行交叉分组对比分析,低脂高龄组病例数明显高于高脂低龄组(43%比20%,P<0.001),但低脂高龄组单支病变明显低于高脂低龄组(11%比32%,P<0.05),4支病变明显高于高脂低龄组(24%比7%,P<0.05)。结论胆固醇的降低不能改变冠心病合并2型糖尿病患者冠状动脉病变特征随增龄而改变的趋势。
Objective To study the influence of serum lipids and age on the angiographical characteristics of the coronary arteries in CHD patients with type 2 diabetes mellitus. Methods The study enrolled 203 CHD patients with type 2 diabetes mellitus and their coronary angiography were analyzed according to their age and lipid levels. Results Most of the patients tended to have multi vessels leisons （ t≥3 branches vs 〈 3 branches was 59.1% vs 40.9%, P 〈 0.01） and higher degree of stenosis （ ≥75% vs 〈 75% was 66% vs 34%, P 〈 0.001）. Compared with the group of patients age 〈60 years old, patients aged ≥60 years old had higher rate of four-branches lesions, less single-vessel lesion and more LM involvement. The were no difference in the number of vessels involved, lesion location and the degree of stenosis between the groups of different lipid levels. The crossed analysis of different age and lipid level groups showed that the number of the patients with older age and normal lipid level was greater than that with younger age and abnomud lipid level （43% vs 20%, P 〈 0.001）, and the former group had less single vessel lesion （ 11% vs 32%, P 〈 0.05） and more four branches lesions than the latter group （24% vs 7%, P 〈 0.05）. Conclusion The decrease in cholesterol level may not affect the progression of coronary leisons along with the increace in age.
出处
《中国介入心脏病学杂志》
2005年第6期371-374,共4页
Chinese Journal of Interventional Cardiology
基金
山东省科技发展计划(2003-35)号
