摘要
目的:探讨激素替代治疗(HRT)对绝经后妇女血清补体C3、CA和免疫球蛋白IgG、IgM水平的影响。方法:将108例绝经妇女随机分为两组,HRT组:服用倍美力0．625mg+安宫黄体酮2．5mg／d,共6个月;对照组:不服用任何激素类药物。于治疗结束后检测妇女血清补体C3、C4和免疫球蛋白IgG、IgM水平。结果:HRT组妇女血清补体C3、C4水平较对照组明显升高(P<0．01),两组血清免疫球蛋白IgG、IgM无显著差异。结论:炎症反应因子补体C3、C4水平升高可能是绝经后妇女应用HRT后心血管疾病发生率增加的原因之一。
Objective： To evaluate the effect of hormone replacement therapy（HRT） on serum complement and immunoglobulin levels in post-menopausal women. Methods： 108 cases healthy post-menopausal women were divided into two groups： 54 women received CEE 0. 625 mg＋ MPA2.5mg per day for six months（HRT group）, 54 women not receiving any therapy （Controls group）. The serum C3, C4, IgG and IgM levels were assessed in each group. Results： The mean serum C3 and C4 level was significantly higher in HRT group than those in the control group（P〈 0. 01 ）. IgG and IgM levels were similar between two groups. Conclusion：It is concluded that HRT may be involved in the development of cardiovascular disease through inflammatory mechanisms, as suggested by increased serum levels of C3 and C4.
出处
《中国临床医学》
北大核心
2005年第6期1076-1077,共2页
Chinese Journal of Clinical Medicine
关键词
激素替代治疗
补体
免疫球蛋白
Hormone replacement therapy
Complement
Immunnglobulin
