摘要
目的探讨多潘立酮(Dom)对正常人胆囊(GB)排空功能的影响。方法采用随机、双盲及自身对照的方法,应用超声检查研究了 Dom 对正常人 GB 排空功能的作用。结果口服 Dom 后 GB 排空减慢,餐后30min 20mg Dom(Dom_2)使 GB排出量(GBEF)明显减少(P<0.05),餐后60min 减少更著(P<0.01)。10mg Dom(Dom_1)虽使 GBEF 减少,但不显著(P>0.05)。GBEF 减少Dom_2明显较 Dom_1为著(P<0.05-0.01)。餐后60min Dom_2使 GB 排空速度明显较未服 Dom 及 Dom_1为慢(P<0.05)。最大 GBEF Dom_2显著少于未服 Dom 及 Dom_1(P<0.01)。结论口服 Dom_2具有显著地减少GB 排空的作用。本研究为 Dom 的合理应用提供理论根据。
AIMS To investigate the effects of domperidone(Dom)on gallbladder (GB)emptying in normal persons. METHODS The effects of Dom on GB emptying in 18 normal subjects were studied by ultrasonography according to randomized,double- blind and self-controlled protocol. RESULTS GB emptying was slow after oral Dom.GB ejection fraction (GBEF)was significantly decreased at postprandial 30 min after oral 20 mg Dom(P<0.05),and the decrease was more significant 60 min after the meal(P<0.01)o A marked difference was found between 10 mg Dom and 20 mg Dom on GBEF after the meal.No significant dif- ference was found between 10 mg Dom and without Dom(P>0.05) although 10 mg Dom made GBEF decreased.The speed of GB empty- ing was slower,and the maximum GBEF was significantly less in 20 mg Dom than in 10 mg Dom and no Dora after the meal(P<0.01). CONCLUSIONS The present study shows that 20 mg Dom has a signifi- cantly inhibiting effect on GB emptying through inhibiting GB con- traction or relaxation of Oddi sphincter,which provides an evidence for reasonable usage of Dom.
