摘要
用RT-PCR半定量分析结果显示,Graves病甲状腺组织及甲状腺腺瘤瘤旁正常甲状腺组织(各5例)均存在褪黑素受体亚型mt1mRNA的表达,未检测到MT2亚型。手术时经药物控制甲状腺功能已正常的Graves病与甲状腺机能仍亢进的Graves病甲状腺组织mt1表达量无差异(P>0.05);Graves病甲状腺组织mt1表达量较正常甲状腺组织明显增加(P<0.01)。提示褪黑素的免疫调节作用可能通过mt1介导,Graves病发病可能与mt1亚型激活有关。
The differential expression of melatonin receptor subtypes by thyroid tissues of Graves＇ disease （n = 5 ） and normal tissue at the vicinity of resected thyroid adenoma （n = 5 ） was determined by RT-PCR. Melatonin receptor subtype mt1 was expressed in Graves＇ disease and normal thyroid tissue, but melatonin receptor subtype mt2 was not expressed. The expression of mt1 in Graves＇ disease showed no significant difference （ P 〉 0.05） between euthyroid and hyperthyroid status when thyroid tissue was obtained. Mt1 in thyroid tissue of Graves＇ disease had a higher quantity than that in normal thyroid tissue （ P 〈 0. 01 ）. The results suggest that the immunomodulatory role of melatonin appears to be mediated by mt1 subtype and the activation of mt1 subtype in thyroid tissue seems to be connected with the pathogenesis of Graves＇ disease.
出处
《中华内分泌代谢杂志》
CAS
CSCD
北大核心
2005年第6期552-553,共2页
Chinese Journal of Endocrinology and Metabolism
