摘要
目的:研究应用磁共振弥散张量成像(DTI)检测和定量分析儿童脑梗死后皮质脊髓束Wallerian变性的可行性。材料和方法:对11例单侧大脑中动脉供血区脑梗死的患儿进行了DTI研究。通过放置兴趣区(ROI)的方式获得定量部分各向异性(FA)和平均弥散量(MD)。ROI放置的部位包括:脑梗死区、脑梗死同侧内囊后支和大脑脚,以及上述部位对侧相应区域。应用Mann-WhitneyU检验确定差异有无显著性。结果:脑梗死同侧皮质脊髓束FA较对侧明显下降(P=0.05),但MD改变无明显差异。结论:应用FA,DTI可以检测并定量分析儿童脑梗死后皮质脊髓束Wallerian变性。
To evaluate DTI, using fractional anisotropy （FA） and mean diffusivity （MD）, can detect and quantify Wallerian degeneration in pediatric infarction. Materials and Methods： Eleven children with unilateral MCA infarction were recruited. Quantitative FA and MD, obtained by manually placing regions-of-interest （ROI） within the infarction, and along the ipsilateral corticospinal tract, i.e. the posterior limb of the internal capsule and cerebral peduncle, were compared with matched contralateral regions using the Mann-Whitney U-test.Results： The FA, but not the MD, of the ipsilateral corticospinal tract was significantly different compared to the normal side（P=0.05）. Conclusion： DTI, using FA, can detect and quantify WD in paediatric infarction.
出处
《中国医学计算机成像杂志》
CSCD
2005年第6期367-369,共3页
Chinese Computed Medical Imaging
