摘要
目的制备具有与自然骨类似表面性能的植体材料纳米羟基磷灰石[Ca10(PO4)6(OH)2,HAp]涂层/钛基复合材料。方法电泳沉积法(EPD)。为改善涂层与基体之间的结合,对钛表面进行了粗糙化和氧化处理。结果烧结前后,涂层成分没有发生变化,具有纳米结构,表面均匀无裂缝。体外干细胞培养试验结果表明,细胞在材料表面和周围生长良好,繁殖速度比钛和常规尺寸的HAp涂层快。结论纳米涂层具有均匀的纳米结构,表现出良好的生物相容性,有望用于设计骨科和齿科材料。
Objective To get a bone-substitute material by coating hydroxyapatite nanoparticle on titanium surface. Methods Titanium surface was roughened and oxidized for improving the bonding strength between hydroxyapatite coating and titanium, then, hydroxyapatite nanoparticle were coated on titanium surface by electrophoretic deposition. Results The nanostructure and component of the coated hydroxyapatite showed no change before and after heat treatment, The coating was uniform and showed no cracks, Moreover, a preliminary study of the bioactivity in vitro showed that mesenchymal stem cells exhibited higher cell proliferation potential on the hydroxyapatite nanoparticle/titanium coating than on the titanium or hydroxyapatite with normal particle size alone. Conclusions Hydroxyapatite nanoparticles-coated titanium implant possesses good biocompatibility, suggesting that the implant could be used in orthopaedics and dental surgery.
出处
《广东药学院学报》
CAS
2005年第6期652-654,660,共4页
Academic Journal of Guangdong College of Pharmacy
基金
国家自然科学基金(20273055)
广东药学院科研基金
