摘要
目的:探讨黄体功能不足患者治疗前后子宫内膜雌激素受体(ER)、孕激素受体(PR)的表达,为临床内分泌治疗和预后判断提供理论依据。方法:对月经周期分泌早期行子宫内膜诊刮经病理证实为黄体功能不足的45例受试患者,按服药前后分为治疗前组与治疗后组,采用免疫组化方法检测子宫内膜ER、PR水平。结果:治疗前组的子宫内膜PR水平明显低于治疗后组,(P<0.05);而治疗前组的子宫内膜ER水平无显著性差别(P>0.05)。结论:黄体功能性不足与子宫内膜局部PR含量不足有关,补充外源性孕激素可使子宫内膜PR水平升高,能达到治疗的作用。(2)子宫内膜的PR可能做为黄体功能性不育的检测指标。
Objective： To study the relationship between endometrium receptor of Estrogen Receptor （ER） and Progesterone Receptor （PR） in infertile women with Luteal insufficiency. Methods： Pathology was done on endometrium in 45 cases and determined as Luteal insufficiency, These cases were divided into before-treatment group and after-treatment group. ER and PR expressions were measured by immunohistochemical method. Results： Comparing with two group PR levers, in before-treatment group they were more lower than in after-treatment group （P〈0.05）; their ER levels had no significance, （P〉 0.05）. Conclusion： It indicated that the external Progesterone may improve the luteal function of the infertile women of Luteal insufficiency and PR is a measure method for infertile women of Luteal insufficiency.
出处
《天津医科大学学报》
2005年第4期577-579,共3页
Journal of Tianjin Medical University
关键词
黄体功能不足
雌激素受体
孕激素受体
Luteal insufficiency
Estrogen Receptor
Progesterone Receptor
