摘要
目的探讨突发性感音神经性聋(突聋)的免疫功能变化。方法采用散射比浊法和间接免疫荧光法测定突发性感音神经性聋病人体液免疫及外周血T细胞表型,并与健康对照组进行比较。结果108例突发性感音神经性聋病人体液免疫功能IgG、IgA、IgM、C3、C4浓度分别是(9.81±3.12)g/L,(2.24±0.97)g/L,(1.75±2.94)g/L,(0.97±0.33)g/L,(0.25±0.22)g/L,与健康对照组比较差异无统计学意义,外周血T细胞亚群CD3+、CD4+、CD8+、CD4/CD8分别是62.64±11.86,37.42±10.17,26.08±9.41,1.64±0.75,较健康对照组均减少,其中CD3+、CD4+细胞数量减少有统计学意义(P<0.05)。结论突发性感音神经性聋病人有一定的细胞免疫功能障碍。
Objective To detect the immunological function in patients with sudden sensorineural hearing loss （SSNHL）. Methods The peripheral blood T lymphocyte subsets in SSNHL patients was measured by indirect immumofluorescence analysis, and the serum immunoglobulin concentrations was detected by nephelometry immunoassay. Results The average concentration of serum IgG, IgA, IgM, （23, CA in 108 SSNHL patients was （9.81 ± 3.12） g/L, （2.24±0.97） g/L, （1.75 ±2.94） g/L, （0.97±0.33） g/L and （0.25 ± 0.22） g/L, respectively, which was not significantly different from those in healthy controls. The average numbers of peripheral CD3^＋ , CD4^＋ , CD8＋ , CIN/ CD8 T lymphocyte in SSNHL patients was 62.64 ± 11.86, 37.42 ± 10.17, 26.08 ± 9.41, 1.64 ± 0.75, respectively, in which CD3^＋ , CD4^＋ cells significantly decreased as compared with those in healthy controls （ P 〈0.05）. Conclusion The immunological function, especially T cell function, in SSNHL patients is changed, which may related to SSNHL genesis and development.
出处
《中国耳鼻咽喉颅底外科杂志》
CAS
2005年第6期381-383,共3页
Chinese Journal of Otorhinolaryngology-skull Base Surgery
关键词
突发性感音神经性聋
体液免疫
细胞免疫
Sudden sensorineural hearing loss fness
Humoral immunity
Cellular immunity
