摘要
目的观察特发性血小板减少性紫癜患者幽门螺旋杆菌根治后血小板恢复情况。方法 30例患者在治疗前后测血常规及幽门螺旋杆菌(HP),后者用13-C尿素呼吸实验测定。用质子泵抑制剂及两种抗生素根治HP。结果30例(ITP)患者中有21例HP阳性,阳性率为70％,HP根治率为85．7％(18／21)。1例患者因4d时出现皮疹停止治疗。10例患者(55．6％)患者血小板得到恢复。2例复治,HP根除后,血小板恢复。3例无HP感染者,给予同样治疗,血小板无显著增加。此外,根治治疗不影响胃溃疡患者血小板计数。结论ITP合并HP感染患者,HP根治可作为一线治疗。
Objective To investigate the prevalence of H. pylori infection and the effectiveness of its eradication in Chinese patients with ITP. Metheds H. pylori infection was found in 21 of 30 patients （70.0%） by 13C urea breath test. Results H. pylori was eradicated in 18 of the 21 infected patients （85.7%） by administration of a proton pump inhibitor and two kinds of antibiotics. In only one patient was medication discontinued due to skin rash on the 4th day of treatment. Platelet recovery was obtained in ten patients （55.6%）. In two patients with treatment failure, platelet recovery was obtained after successful re -eradication. In three patients without H. pylori infection, platelet counts did not significantly increase with the same treatment. On the other hand, eradication therapy did not affect platelet counts in patients with gastric ulcer. Conclusion H. pylori eradication can be used for initial treatment with tolerable adverse effects in some ITP patients.
出处
《湖北民族学院学报（医学版）》
2005年第4期19-21,共3页
Journal of Hubei Minzu University(Medical Edition)
关键词
幽门螺旋杆菌
根治
特发性血小板减少性紫癜
Helicobacter pylori
Bacterial eradication Idiopathic thrombocytopenic purpura
