摘要
检测３１例结直肠癌临床术后标本的癌、癌周及相邻正常粘膜组织蛋白激酶Ｃ（ＰＫＣ）活性，结果显示：正常粘膜、癌周及癌组织细胞质、细胞膜ＰＫＣ比活性和总活性依次降低，癌周及癌组织细胞膜／细胞质比率较正常粘膜组织显著增高，表明结直肠癌ＰＫＣ处于激活状态，且呈下降调节。另外，癌组织细胞膜比率（细胞膜／正常粘膜）与肿瘤大小呈负相关，高分化结直肠癌细胞膜比率较低分化显著均高。由此可见，ＰＫＣ活性在结直肠癌发生过程中起重要作用。
protein kinase C(PKC) activity was measured in carcinoma,tissues adjacent to carcinomaand normal tissues of colorectal mucosa from 31 cases of patients with colorectal cancer.The results revedwledthat PKC specific activity in both tissues adjacent to carcinoma and carcinoma was reduced in the cytosolicand mebrane fraction compared with that of normal colorectal mucosa in patients.As for the total PKC ac-tivity,both tissues adjacent to carcinoma and carcinoma showed a significant progressive increase in ratio ofmembrane/cytosolic PKC compared with that of the normal colorectal mucosa in patients,Our data suggest-ed that PKC in colorectal cancer is in an activated state,The study also showed a significant decrease inmembrane ratio (membrane PKC/normal mucosa PKC)in carcinoma correlated with size,The membrane ra-tio was increased in well differentiated colorectal cancer compared with that of poorly differentiated colorec-tal cancer.The resulta snggested PKC activity might play an important role in colorectal carcinogenesis.
出处
《癌症》
SCIE
CAS
CSCD
北大核心
1996年第1期32-34,共3页
Chinese Journal of Cancer
