摘要
目的:探讨肺癌脑转移化疗放射治疗的疗效及毒副作用。方法:45例肺癌脑转移患者采用替尼泊苷(VM26)+顺铂(DDP)方案序贯化疗放射治疗,观察有效率与1、2、3年生存率及毒副作用。结果:非小细胞肺癌脑转移单发、多发转移灶总有效率92.86%、80.94%;小细胞肺癌脑转移单发、多发转移灶总有效率75%、83.33%。非小细胞肺癌脑转移单发、多发转移灶1、2、3年生存率分别为13.33%和14.29%、9.5%和4.76%、9.5%和0;小细胞肺癌脑转移单发、多发转移灶1、2、3年生存率分别为50%和50%、25%和33.33%、25%和16.67%。骨髓抑制Ⅰ度、Ⅱ度、Ⅲ度、Ⅳ度分别为33.33%、28.89%、17.78%、8.89%。结论:肺癌脑转移患者采用VM26(DDP方案序贯化疗放射治疗的疗效较好,毒副作用较轻。
Purpose： To evaluate the efficacy and toxic and side effects of brain metastases of lung cancer treated with chemotherapy and conventional radiotherapy. Methods： 45 cases of brain metastases of lung cancer were treated with sequential chemotherapy of VM26 ＋ DDP regimens and conventional radiotherapy. The complete remission and partial remission rate , 1-, 2-, 3-year survival rate and toxic and side effects were observed. Results： The complete remission and partial remission rate of salitary as well as multiple brain metastases of non-small-cell lung cancer and small-cell lung cancer were 92.86%, and 80.94%, 75% and 83.33%, respectively . The 1-, 2-, 3-year survival rate of salitary and multiple brain metastases of non-small-cell lung cancer was 13.33% and 14.29% ,9.5% and 4.76% ,9.5% and 0. The 1-, 2-, 3-year survival rate of salitary and multiple brain metastases of small-cell lung cancer were 50% and 50% ,25% and 33.33% ,25% and 16.67%, respectively. The Ⅰ,Ⅱ,Ⅲand Ⅳ degree myelosuppression was 33.33%, 28.89%, 17.78%, 8.89%, respectively. Conclusions： The efficacy of brain metastases of lung cancer treated with sequential chemotherapy by VM26 ＋ DDP regimens and conventional radiotherapy is better and with less toxic and side effects.
出处
《中国癌症杂志》
CAS
CSCD
2005年第6期554-556,共3页
China Oncology
关键词
肺癌
脑转移
序贯化疗放射治疗
疗效
毒副作用
lung cancer
brain metastases
sequential chemotherapy and traditional radiotherapy
efficacy
toxic and side effects
