摘要
目的探讨血色素指数(IHb)色图测定对上消化道病变的诊断价值。方法采用OlympusGIF-H260型电子内镜对280例患者进行观察,选择一定区域记录IHb色图,在相应部位取活组织做病理组织学检查,并采用免疫组化染色方法计数微血管密度。结果与正常黏膜相比,炎症浸润重的黏膜IHb值高而萎缩的黏膜IHb值低(P<0.05);中晚期肿瘤的IHb值多明显高于癌周黏膜;分化好的早期癌的IHb值高而分化差的早期癌的IHb值低(P<0.05);黏膜下良性病变的IHb值与周边黏膜相比无明显差异;黏膜层微血管密度(MVD)是影响IHb值的重要因素,IHb高的区域,其MVD也较高(P<0.01)。结论IHb色图对微小病灶的检出、病灶性质的判断以及病灶范围的确定有一定的临床意义,有望拓展内镜的诊断性能。
Objective To evaluate the value of IHb map in upper gastrointestinal endoscopy. Methods IHb map images was observed in 280 patients with different upper gastrointestinal tract lesions using Olympus GIF-H260 gastroendoscope. Biopsies were taken and microvessel density （MVD） were examined by immunohistochemical staining. Results IHb values were higher in the specimens of more in flammatory cell infiltration and lower in those of higher degree of atrophic changes （ P 〈 0. 05 ）. IHb values seemed to be related to tumor differentiation. An increased IHb values was more frequently observed in differentiated carcinoma than in undifferentiated carcinoma （P 〈0.05 ）. No IHb changes was found in benign submucosal lesions. The higher of IHb value, the higher of MVD. Conclusion Measurement of IHb map is useful in detecting minimal lesion in upper gastrointestinal tract, distinguishing the benign from the malignant and determining the extent of the lesion. It is promising to extend the diagnostic ability of endoscopy.
出处
《第三军医大学学报》
CAS
CSCD
北大核心
2005年第23期2357-2359,共3页
Journal of Third Military Medical University
