摘要
目的:探讨POEMS综合征患者骨髓病理学的特点。方法:对3例POEMS综合征患者进行骨髓穿刺及活检、免疫组化检查,分析其骨髓学改变的特点。结果:骨穿2例正常;1例有浆细胞升高;3例骨髓活检及免疫组化检查均出现异常,活检呈散在或灶性的成熟浆细胞及浆母细胞浸润,免疫组化提示为反应性浆细胞增生或意义不明的单克隆γ球蛋白病。结论:POEMS综合征患者的骨髓病理学表现介于正常骨髓和恶性淋巴瘤之间的一种过渡类型的异常改变。
Aim：To investigate the pathological changes of the bone marrow in patients with POEMS syndrome. Methods： 3 patients underwent bone marrow puncture, biopsy and immunohistochemical examination and the pathological changes were analyzed. Results：The bone marrow puncture results of 2 patients are normal and another one shows an elevation of plasma cells; the biopsy and the immunohistochemical results of all the 3 patients are abnormal. The biopsy displays a disperse or focal infiltration of mature plasma cells and plasmoblasts. The results of the immunohistochemical examination suggest a reactive plasma cell proliferation or a somewhat monoclonal （M） ganunopathy. Conclusion： The pathological change of the bone marrow in POEMS syndrome is a kind of transitional expression which is between that of the normal bone marrow and the malignant lymphoma.
出处
《中国临床神经科学》
2005年第4期380-384,共5页
Chinese Journal of Clinical Neurosciences
