摘要
Urotensin II最早是从鱼尾部下垂体中分离出的神经环肽,随后在一种欧洲绿蛙Rana ridibunda的脑中鉴别出来和从人体基因组中克隆出来。人Urotensin II(human urotensin II,hUII)有11个氨基酸残基组成,主要分布于心血管和神经系统。作为UT受体的一种内源性配体,hUII有广泛的生物学效应,如收缩和舒张血管,促进心肌细胞增殖,调节心功能,并在冠心病、心功能衰竭等某些心血管疾病的病理过程中起着重要的作用。本文就hUII在心血管系统方面的生物学效应作一简要的综述。
Urotensin Ⅱ （U-Ⅱ）, a cyclic peptide has been initially identified as a neuropeptide of teleost fish. Subsequently, U-Ⅱ has been characterized in the brain of the European green frog and has also been cloned from the human genome. Human U-Ⅱ （human U-Ⅱ, hU-Ⅱ）, composed of 11 amino acid residues is rich in cardiovas- cular and nervous system. As an endogenous ligand for UT receptor, hU-II exerts a broad spectrum of biologicalactions, such as vasoconstriction and vasorelaxation, facilitating proliferation of cardiac cells, regulating the cardiac function and playing an important role in pathogenesis of some cardiovascular diseases such as coronary heart disease and cardiac failure. The effects of hU-Ⅱ on cardiovascular system were briefly reviewed as follows.
出处
《中国临床药理学与治疗学》
CAS
CSCD
2005年第11期1210-1214,共5页
Chinese Journal of Clinical Pharmacology and Therapeutics
基金
安徽省海外留学人才资金资助(№2005Z031)
