摘要
化疗是血液肿瘤的主要治疗手段,但目前存在的关键问题是肿瘤细胞对化疗药物产生多药耐药(MDR)。这种现象由多种耐药机制导致,包括了如过度表达耐药相关蛋白的生化机制和涉及造血微环境的生理机制等。本文简要回顾了MDR的产生机制和逆转策略方面的研究进展,重点讨论了MDR的检测和结果分析,以及和造血微环境的关系。
Chemotherapy remains a major route of intervention in hematological malignancies. However,a key issue in the treatment of hematological malignancies is the development of multidrug resistance （MDR） to chemotherapeutic drugs. Several mechanisms may account for this phenomenon, including biochemical mechanisms, such as the overexpression of resistance-conferring proteins and physiological mechanisms involving the hematopoietic microenvironment. In this article the pathomechanism, diagnostic approach, interpretation of results from clinical samples and correlations with hemopoietic microenvironment were briefly reviwed. The aspects of development and problems in MDR study as well as detection methods for MDR were also discussed.
出处
《中国实验血液学杂志》
CAS
CSCD
2005年第6期1151-1154,共4页
Journal of Experimental Hematology
关键词
血液肿瘤
多药耐药
造血微环境
hematological malignancy
multidrug resistance
hematopoietic microenvironment
