摘要
目的探讨尿蛋白电泳和尿β2微球蛋白(β2M)联合检测在肾小管间质损伤中的诊断价值。方法应用十二烷基硫酸钠琼脂糖凝胶电泳(SDSAGE)测定尿蛋白,放射免疫法测定尿β2M。结果肾小管间质损伤组尿蛋白电泳出现管性蛋白明显多于正常对照组,尿β2M显著高于正常对照组。70例肾小管间质损伤患者尿蛋白电泳出现管性蛋白44例,尿β2M升高41例,两种指标联合检测出肾小管间质性损害53例。结论尿蛋白电泳和尿β2M联合检测,可作为肾小管间质损伤早期诊断敏感的实验指标。
Objective To study the diagnostic value of the combinative measuring of proteinuria electrophoresis and urinary β2-M in renal tubular interstitial damage. Methods The proteinuria detected with sodium dodecyl sulfate-argarose gel electrophoresis（SDS-AGE） and the urinary β2-M detected with radioimmuno assay were used to analyze 70 urine samples from patients with renal tubular interstitial damage. Results The tubular proteinuria in the renal tubular interstitial damage group was significant more than that in the normal group. The urinary β2-M in the renal tubular interstitial damages group were significant higher than that in the normal group. There were 44 cases of tubular proteinuia and 41 cases of urinary β2-M increasing in 70 urine samples from patients with the renal tubular interstitial damage. There were 53 urine samples diagnosed renal tubular interstitial damage combinalively measured with the two methods. Conclusion The combinative measuring of proteinuria electrophoresis and urinary β2-M can be used as sensitive indexes for the early diagnosis of the renal tubular interstitial damage.
出处
《国外医学（临床生物化学与检验学分册）》
CAS
2005年第12期885-886,888,共3页
Foreign Medical Sciences(section of Clinical Biochemistry and Laboratory Medicine
关键词
电泳
Β2微球蛋白
肾炎
间质性
实验技术和方法
Electrophoresis
Beta 2-microglobulin
Nephritis, interstitial
Laboratory techniques and procedures
