摘要
目的:观察丙泊酚联合瑞芬太尼用于无痛人工流产术的安全性与可行性,并与丙泊酚联合氧化亚氮的方法进行比较.方法:选择100例需无痛人工流产的早期妊娠妇女,随机分为两组,丙泊酚联合瑞芬太尼组(PR组)与丙泊酚联合氧化亚氮组(PN组),每组50例.PR组:缓慢静脉推注瑞芬太尼1μg/kg后,继以丙泊酚1～1.5 mg/kg静脉推注;PN组:经面罩吸入50%氧气与50%氧化亚氮混合气体,直至临近手术结束,吸气开始时,静注丙泊酚1.5～2mg/kg.观察患者的循环、呼吸情况,麻醉镇痛效果,苏醒时间、离院时间,以及丙泊酚的总用量和术中的一些不良反应.结果:两组麻醉前、诱导后及术毕的血压、心率均无显著性差异(P＞0.05),诱导后PR组的呼吸抑制发生率、氧饱和度与基础值及PN组同时点的值相比,显著下降(P＜0.01),PR组的苏醒时间、离院时间及丙泊酚总用量均显著小于PN组(P＜0.01),两组患者的镇痛优良率均为100%,无显著性差异(P＞0.05).结论:丙泊酚联合瑞芬太尼用于无痛人工流产术安全可行.
Objective： To investigate the safety and feasibility of propofol and remifentanil used in induced abortion, and compared with propofol and nitrous oxide. Methods： One hundred early pregnant women were randomly divided into two groups （n = 50 in each ） ： propofol and remifentanil group （PR group）, propofol and nitrous oxide group（ PN group）. PR group was administrated remifentanil 1 1μg/kg and propofol 1 - 1.5 mg/kg;PN group： inhaled mixed 50% nitrous oxide-50% oxygen till operation nearly finished, and propofol 1.5 - 2 mg/kg was infused at the beginning of inhalation. The indications of circulation and respiration, the awake time and post-operation session in hospital, the total dosage of propofol were recorded, additionally, the analgesic effects and side effects were also observed. Results ： There was no significantly difference in MAP and HR among premedication, post-induction and at the end of operation in two groups （P 〉 0. 05 ）. After induction, a significant decrease in SpO2 and remarkable respiratory depression were founded in PR group（ P 〈 0. 01 ）. The awake time and post-operation session in hospital were significantly shorter in PR group than in PN group, the total dosage of propofol was also significantly less （P 〈 0. 01 ）. No significant difference in analgesic effects and side effects were observed between the two groups. Conclusion： Propofol combined with remifentanil in induced abortion was safe and feasible.
出处
《江苏大学学报（医学版）》
CAS
2005年第6期488-490,共3页
Journal of Jiangsu University：Medicine Edition
关键词
丙泊酚
瑞芬太尼
氧化亚氮
人工流产
Propofol
Remifentanil
Nitrous Oxide
Induced abortion
