摘要
目的研究甲磺酸达氟沙星的合成工艺。方法以反-4-羟基-L-脯氨酸为起始原料,经N-保护、还原、酰化、环合、脱保护、缩合、成盐7步反应得到甲磺酸达氟沙星。结果与结论该法操作简便,更有利于工业化生产,甲磺酸达氟沙星总收率达50%(以脯氨酸计)。
Aim To improve the synthetic process of danofloxacin mesylate from trans-4-hydroxyl-L-proline, Methods The reaction process include N-protection, reduction, chlorination, cyclization, deprotection, condensation and salt formation. Results and conclusions The total yield was 50 %. The new synthesis course is better than that reported in literature and might be applied to industrial production.
出处
《中国药物化学杂志》
CAS
CSCD
2005年第6期354-356,共3页
Chinese Journal of Medicinal Chemistry
关键词
药物化学
工艺改进
化学合成
甲磺酸达氟沙星
medicinal chemistry
process impovement
chemical synthesis
danofloxacin mesylate