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甲磺酸达氟沙星的合成工艺改进

Improved synthesis of danofloxacin
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摘要 目的研究甲磺酸达氟沙星的合成工艺。方法以反-4-羟基-L-脯氨酸为起始原料,经N-保护、还原、酰化、环合、脱保护、缩合、成盐7步反应得到甲磺酸达氟沙星。结果与结论该法操作简便,更有利于工业化生产,甲磺酸达氟沙星总收率达50%(以脯氨酸计)。 Aim To improve the synthetic process of danofloxacin mesylate from trans-4-hydroxyl-L-proline, Methods The reaction process include N-protection, reduction, chlorination, cyclization, deprotection, condensation and salt formation. Results and conclusions The total yield was 50 %. The new synthesis course is better than that reported in literature and might be applied to industrial production.
机构地区 郑州大学药学院
出处 《中国药物化学杂志》 CAS CSCD 2005年第6期354-356,共3页 Chinese Journal of Medicinal Chemistry
关键词 药物化学 工艺改进 化学合成 甲磺酸达氟沙星 medicinal chemistry process impovement chemical synthesis danofloxacin mesylate
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参考文献7

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二级参考文献6

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