摘要
白果清蛋白提取物(Ginkgo albumin extract,GAE)是本实验室首次从白果中分离提取得到的具有较好 抗氧化及延缓衰老活性的水溶性蛋白提取物,本工作探讨了白果清蛋白提取物对8．5 Gy及3．2Gy的γ,射线辐 射损伤小鼠的保护作用。实验结果表明,8．5Gy的γ射线辐射小鼠后,其30d存活率呈显著性下降,辐射对 照组的存活率为0,GAE高剂量给药组为20％;外周血象在辐射后受到不同程度的破坏,与辐射对照组相比, GAE给药组的血象指标下降幅度较小,恢复较快,具有显著性的差异;GAE能显著增加中剂量的γ射线辐射 损伤小鼠血清中超氧化物歧化酶(Superoxide dismutase,SOD)的活性和DNA含量,显著性促进辐射小鼠体 内受损免疫机能的恢复。结果表明,GAE能通过增强辐射损伤小鼠的抗氧化能力、造血功能及体内免疫功能 来起到对辐射损伤小鼠的保护作用。
Water soluble ginkgo albumin extract （GAE）, which was extracted for the first time from seeds of Ginkgo bilbo L in our laboratory, has good antioxidant and anti-aging activity. In this paper, protective effect of GAE on γ-rays irradiated mice was studied. The results showed that the mice irradiated to 8.5 Gy was zero, whereas survival rate of the high dosage GAE group was 20 percent. Blood picture of the 8.5Gy irradiated mice suffered damages of different degrees, while blood picture index of the GAE group decreased slower and recovered faster significantly than the irradiation control group. GAE and Vitamin C could significantly enhance serum SOD activity in serum and increase DNA content in bone marrow cells, and also promote recovery of damaged immunology function of the irradiated mice. These suggest that GAE may protect mice from the radiation damages by enhancement of antioxidant activity, hemopoiesis function and immunologic function of mices.
出处
《辐射研究与辐射工艺学报》
EI
CAS
CSCD
北大核心
2005年第6期359-365,共7页
Journal of Radiation Research and Radiation Processing
基金
湖北省"十五"攻关基金(2001AA204802)资助
关键词
白果清蛋白提取物
γ射线辐射
免疫功能
抗氧化能力
造血功能
保护作用
Ginkgo Albumin Extract, T-ray irradiation, Antioxidant activity, Hemopoiesis function, Immunologic function, Protect effect
