摘要
对乙酰氨基酚是常用的解热镇痛药,中毒剂量时形成大量的中间代谢产物N-乙酰-对苯醌亚胺,可导致以急性小叶中央型坏死为特征的肝脏损害。特别是在感冒患者为增强疗效而同时合用多种含对乙酰氨基酚的复方制剂时,可无意中增强其毒性作用,易致中毒事件发生。临床上,对乙酰氨基酚中毒主要表现为“药物性肝炎”或“暴发性肝衰”的改变。同时综述了以N-乙酰半胱氨酸为主的特异解毒药及其它急救措施。
Acetaminophen is a popular analgesic. When its taken in toxic doses, an intermediate meabolite, N-acetyl-para-benzo-quinoneimine is largaly formed. Thus, The hapatic necrosis in going on meanwhile, Some patients medicate several preparations simultaneonsly for increasing therapeutic effects, which may increase acetaminophen poisoning. The main clinical manifestation of the acetaminophen poisoning are drug-induced hepatitis and fulminant hepatic failure moreover. This article reviews some special antidotes and emergency treatments.
出处
《药物流行病学杂志》
CAS
1996年第3期159-162,共4页
Chinese Journal of Pharmacoepidemiology
