摘要
为了探讨肾癌的异型性，对４２例肾癌应用抗ＣＤ_（１５）、抗上皮细胞膜抗原（抗ＥＭＡ）、抗神经元特异性烯醇化酶（抗ＮＳＥ）三种单抗，采用免疫组化ＡＢＣ法联合检测进行分类。肾癌Ａ型（＋、－、－）表达９例，分化好、异型性小、预后最好；肾癌Ｃ型（－、＋、＋）表达１３例，分化差、异型性大、预后最差；其余为Ｂ型，介于Ａ型和Ｃ型之间。结果提示肾癌ＣＤ_（１５）、ＥＭＡ、ＮＳＥ的表达与否，可表明癌细胞是否保留近曲小管上皮细胞的抗原性，可作为判断肾癌异型性的一个指标，与患者预后有关。
Heterogenicity of renal cell carcinoma was detected in 42 cases by means of immunohistochemical method using anti CD15. EMA and NSE antibody. Nine cases were of type A renal cell carcinoma(+、-、 -),being well differentiated, with less heterogenicity and best expectancy. Thirteen were of type C renal cell carcinoma(-、+、+), being poorly differentiated, with much heterogenicity and worst expectancy. Type B was in between type A and type C,Expressions of CD15,EMA and NSE are probably the markers of heterogenicity in renal cell carcinoma and the heterogenicity is related to the prognosis of the patient.
出处
《中华泌尿外科杂志》
CAS
CSCD
北大核心
1996年第9期521-523,共3页
Chinese Journal of Urology
关键词
肾肿瘤
癌
免疫化学
抗体
异型性
Kidney neoplasms
Carcinoma
Immunochemistry
Antibody
