摘要
目的:研究D-二聚体、Hs-CRP水平的变化在指导华法林治疗2型糖尿病伴不稳定型心绞痛中的临床意义。方法:将52例D-二聚体、Hs-CRP均增高的患者52例,分为治疗组和对照组,分别观察他们的INR、心绞痛缓解时间及消失时间、心绞痛发作次数、心肌梗死、脑出血、脑梗死、PCI或CABG等心血管事件变化。结果:治疗组心绞痛缓解时间、消失时间明显缩短,和对照组相比有明显差异。从3月始治疗组心绞痛发作次数与对照组相比明显减少(P<0.05)。到第24月,两组共发生心脑血管事件分别为16和58次,统计学差异显著(P<0.05)。结论:ACS不同时期CRP和D-二聚体有波动性,并以此,指导短期华法林抗凝治疗取得明显疗效,无严重不良反应发生。
Objective： To evaluate clinical significance of the serum C - reactive protein and D - dimer level taken as a guide in treatment of 2 diabetes patients with unstable angina by. use of warfarin.Methods： 52 patients with high level of C- reactive protein and D- dimer were randomly divided into two groups, the warfarin group and the control group. INR, some cardiovascular events such as the duration of relief and disappearance of angina,the frequence of angina,AMI,the episodes of brain bleeding and cerebral infarction , PCI or CABG were monitored. Results： The duration of relief and disappearance of angina in treaunent group was signifi- candy shortened compared with the control group（ P 〈 0.05）, for 3 months of oral warfarin therapy, the frequency of angina was less than that of the control group. In the 24th months 16 and 58 episodes of cardiovascular events occurred in the two groups respectively, which showed a significant difference. Conclusion： The serum level of CRP and D - dimer in different stages of ACS has a significant fluctuation, which can serve a reasonable indicator of significant gain and no severe side - effect during oral anticoagulant therapy.
出处
《医学理论与实践》
2005年第12期1391-1393,共3页
The Journal of Medical Theory and Practice
