摘要
线虫抗凝肽(NAP)是自犬钩口线虫成虫分离得到的一系列具有抗凝作用的小分子多肽类 物质,含有约75-85个氨基酸,拥有22％的共同序列。NAP抗凝作用强,药效持久,成本低,临床 应用前景好,现已进入Ⅲ期临床试验评估阶段。就其研究进展做一综述。
The nematode anticoagulant peptides （NAP）are a family of antithrombotic non-enzymatic peptides of low molecular weights. They are isolated from adult Ancylostoma caninum and are composed of around 75 to 85 amino acids with a homology of 22 % . Since NAPs have demonstrated potent and prominent anticoagulant activity, long halflife, excellent bioavailability, and relative low price, they are developed to be promising therapeutic agents in the treatment and prevention of thrombotic disorders. One of the family members, NAPc2 has entered the Phase Ⅲ clinical trial in the United States of America. Recent progresses on NAP are reviewed.
出处
《中国生物工程杂志》
CAS
CSCD
北大核心
2005年第B04期57-61,共5页
China Biotechnology
基金
山东省科学技术发展计划重大项目资(021100107)
