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皮质酮混合异丙酚对大鼠海马脑片CA1区长时程增强的影响 被引量：1

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摘要 异丙酚是目前临床常用的静脉全麻药物,但是一些应用异丙酚的患者在术后表现出遗忘等记忆功能障碍[1],这可能与异丙酚影响突触的可塑性有关[2].皮质酮是啮齿类动物重要的糖皮质激素,应激反应可以使动物体内皮质酮水平增高,可抑制大鼠海马脑片长时程增强(LTP)的形成[3].长时程抑制(LTD)和LTP是突触可塑性的重要形式,单独应用皮质酮或异丙酚可以易化大鼠海马脑片CA1区LTD的表达,皮质酮混合异丙酚则可以进一步增强LTD表达[4].应激与异丙酚双重因素对于LTP是否产生影响仍不清楚.本研究拟观察皮质酮混合异丙酚对大鼠海马脑片CA1区LTP的影响.
作者 尚游 姚尚龙 江山 曾因明
机构地区 华中科技大学同济医学院协和医院麻醉学教研室 徐州医学院江苏省麻醉学重点实验室
出处 《中华麻醉学杂志》 CAS CSCD 北大核心 2005年第10期783-784,共2页 Chinese Journal of Anesthesiology
基金 江苏省教育厅开放课题(KJS03084)
关键词 海马脑片CAl区 长时程增强 CA1区 异丙酚 皮质酮 大鼠 突触可塑性 记忆功能障碍 应激反应 糖皮质激素
分类号 R96 [医药卫生—药理学]
  • 相关文献

参考文献9

  • 1Barr G, Anderson RE, Owall A, et al. Being awake intermittently during propofol-induced hypnosis: a study of BIS, explicit and implicit memory.Acta Anaesthesiol Stand, 2001, 45 : 834-838. 被引量：1
  • 2Wei H, Xiong W, Yang S, et al. Propofol facilitates the development of long-term depression and impairs the maintenance of long-term potentiation in the CA1 region of the hippocampus of anesthetized rats.Neurosci Lett, 2002, 324: 181-184. 被引量：1
  • 3Zhou J, Zhang F, Zhang Y. Corticosterone inhibits generation of long-term potentiation in rat hippocampal slice: involvement of brain-derived neurotrophic factor. Brain Res, 2000, 885: 182-191. 被引量：1
  • 4谢玉波,徐林,曾邦雄,李兴旺.皮质酮复合异丙酚对大鼠海马CA1区长时程抑制的影响[J].中华麻醉学杂志,2005,25(2):130-132. 被引量：1
  • 5Malenka RC, Nicoll RA. Long-term potentiation-a decade of progress?Science, 1999, 285: 1870-1874. 被引量：1
  • 6Simon W, Hapfelmeier G, Kochs E, et al. Isoflurane block synaptic plasticity in the mouse hippocampus. Anesthesiology, 2001, 94: 1058-1065. 被引量：1
  • 7Baker KB, Kim JJ. Effects of stress and hippocampal NMDA receptor antagonism on recognition memory in rats. Learn Mem, 2002, 9 : 58-69. 被引量：1
  • 8Grover LM, Yan C. Blockade of GABAA receptors facilitaties induction of NMDA receptor-independent long-term potentiation. J Neurophysiol,1999, 81: 2814-2822. 被引量：1
  • 9Yamakura T, Sakimura K, Shimoji K, et al. Effect of propofol on various AMPA-, kainate- and NMDA-selective glutamate receptor channelse xpressed in Xenopus oocytes. Neurosci Lett, 1995, 188:187-190. 被引量：1

二级参考文献13

  • 1Wei H, Xiong W, Yang S, et al. Propofol facilitates the development of long-term depression (LTD) and impairs the maintenance of long-term potentiation (LTP) in the CA1 region of the hippocampus of anesthetized rats. Neurosci Lett, 2002,324:181-184. 被引量：1
  • 2Barr G, Anderson RE, Owall A, et al. Being awake intermittently during propofol-induced hypnosis: a study of BIS,explicit and implicit memory.Acta Anaesthesiol Scand, 2001, 45: 834-838. 被引量：1
  • 3Andrade J, Englert L, Harper C, et al. Comparing the effects of stimulation and propofol infusion rate on implicit andexplicit memory formation. Br J Anaesth, 2001, 86:189-195. 被引量：1
  • 4Xu L, Holscher C, Anwyl R, et al. Glucocorticoid receptor and protein/RNA thesis-dependent mechanisms underlie the control of plasticity synaptic by stress. Proc Natl Acad Sci USA, 1998, 17:3204-3208. 被引量：1
  • 5Xu L, Anwyl R, Rowan MJ. Behavioural stress facilitates the induction of long-term depression in the hippocampus. Nature, 1997, 387:497-500. 被引量：1
  • 6Misner DL, Sullivan JM. Mechanism of cannabinoid effects on long-term potentiation and depression in hippocampal CA1 neurons. J Neurosci,1999, 19:6795-6805. 被引量：1
  • 7Kim JJ, Ycon KS. Stress: metaplastic effects in the hippocampus. Trends Neurosci, 1998, 21:505-509. 被引量：1
  • 8Patel NV, Finch CE. The glucocorticoid paradox of caloric restriction in slowing brain aging. Neurobiol Aging, 2002, 23:707-717. 被引量：1
  • 9Pavlides C, Ogawa S, Kimura A, et al. Role of adrenal steroid mineralocorticoid and glucocorticoid receptors in long-term potentiation in the CA1 field of hippocampal slices. Brain Res, 1996, 738:229-235. 被引量：1
  • 10Pavlides C, Watanabe Y, Magarinos AM, et al. Opposing roles of type Ⅰand type Ⅱ adrenal steroid receptors in hippocampal long-term potentiation. Neuroscience, 1995, 68: 387-394. 被引量：1

同被引文献12

  • 1Jones C,Griffiths RD,Humphris G. Disturbed memory and amnesia related to intensive care[J]. Memory, 2000; 8: 79- 94. 被引量：1
  • 2Wang M, yang Y, Dong Z, et al. NR2B-containing N-methyl- D-aspartate subtype glutamate receptors regulate the acute stress effect on hippocampal long-term potentiation/long-term depression in vivo [J]. Neuroreport, 2006; 17:1343 - 1346. 被引量：1
  • 3Nagashima K, Zorumski CF, Izumi Y. Propofol inhibits longterm potentiation but not long-term depression in rat hippoeampal slices[ J ]. Anesthesiology, 2005 ; 103 : 318 - 326. 被引量：1
  • 4Zhong WX, Dong ZF, Tian M, et al. N-methyl-D-aspartate receptor-dependent long-term potentiation in CA1 region affects synaptic expression of glutamate receptor subtmits and associated proteins in the whole hippocampus [J]. Neuroscience, 2006; 141 : 1399 - 1413. 被引量：1
  • 5Kullmann DM, Asztely F, Walker MC. The role of mammalian ionotropic receptors in synaptic plasticity: LTP, LTD and epilepsy[J]. Cell Mol Life Sci, 2000; 57:1551 - 1561. 被引量：1
  • 6Pawelzik H, Bannister AP, Deuchars J, et ol. Modulation of bistratified cell IPSPs and basket cell IPSPs by pentobarbitone sodium, diazepam and Zn^2+ : dual recordings in slices of adult rat hippocampus[J]. Eur J Neurosci, 1999; 11:3552 - 3564. 被引量：1
  • 7Gilbert ME, Mack CM. Field potential recordings in dentate gyms of anesthetized rats: stability of baseline[J]. Hippocampus, 1999;9:277 - 287. 被引量：1
  • 8Takamatsu I, Sekiguchi M, Wada K, et ol. Propofol-mediated impairment of CA1 long-term potentiation in mouse hippocampal slices[J]. Neurosci kett, 2005;389:129- 132. 被引量：1
  • 9Dineley KT, Weeber E J, Atkins C, et ol. leitmotifs in the biochemistry of LTP induction: amplification, integration and coordination[J]. J Neurochem, 2001; 77:961-971. 被引量：1
  • 10Man HY, Ju W, Ahmadian G, et ol. Intracellular trafficking of AMPA receptors in synaptic plasticity[J]. Cell Mol Life Sci, 2000; 57: 1526- 1534. 被引量：1

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中华麻醉学杂志
2005年 第10期

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