摘要
目的观察乳腺叶状肿瘤病理特点,探讨其恶性间质成分可能来源。方法收集叶状肿瘤患者标本30例,复查临床资料,采用免疫组化染色方法观察细胞标记物波形蛋白、细胞角蛋白、结蛋白和肌动蛋白的表达,并观察其中2例叶状肿瘤的超微结构。结果30例叶状肿瘤间质细胞均未见角蛋白和结蛋白表达,而波形蛋白表达均为阳性,肌动蛋白表达6例强阳性,5例阳性,10例弱阳性,9例阴性。超微结构观察发现肿瘤细胞呈长梭形,细胞外有大量胶原原纤维,细胞核大,核外形不规则,胞浆少,细胞器少见。结论叶状肿瘤间质细胞来自导管周围成纤维细胞,具有平滑肌和肌纤维母细胞分化能力。
Objective To observe the pathologic characteristics of breast phyllodes tumor and discuss the histological origin of malignant stroma. Methods Thirty cases of paraffin blocks of phyllodes tumor were collected and clinical material of the patients were reviewed. The expression of vimentin,cytokeratin,desmin and actin were immuohistochemically detected. And the ultrastructure of phyllodes tumor was studied by electroscope in 2 cases of phyllodes tumor. Results No expression of cytokeratin and desmin were found in all of the 30 cases, and positive ex＇pressions of vimentin were found in all of the 30 cases. The positive expressions of actin were different in the 30 cases of phyllodes tumor （6 cases strong positive, 5 cases positive, 10 cases weak positive, and 9 cases negative）. Conclusion Neoplastic cells of phyllodes tumor are probably derived from periductal fibroblast and it can differentiate to smooth muscle and myofibroblast.
出处
《重庆医学》
CAS
CSCD
2005年第12期1782-1784,共3页
Chongqing medicine
关键词
乳腺叶状肿瘤
间质
免疫组织化学
透射电镜
breast phyllodes tumor
stroma
immunohistochemistry
transmission electron microscopy
