摘要
本文应用免疫组化方法对120例卵巢上皮性肿瘤（其中囊腺癌60例，交界性囊腺瘤及良性囊脉瘤各30例）进行了癌基因C－rasp21及PCNA基因蛋白表达的研究．结果表明：C－rasp21在卵巢囊腺癌的阳性率为81．5％；在交界性囊腺瘤的阳性率为60．6％；明显高于良性囊腺瘤17．2％的阳性率，具有显著差异性（P＜0．01）．PCNA阳性表达超过65％的在囊腺癌中占88．25％；交界性囊腺瘤中占56．6％，与良性囊腺瘤相比有显著差异性（P＜0．01）．结果提示：在卵巢囊腺肿瘤切片上，检测C－rasp21表达阳性率及PCNA的细胞增殖分数，对于判断卵巢囊腺瘤的良恶性及分级具有较大意义．另还提示：C－rasp21与PCNA共同表达阳性病例术后平均生存期较短，并与肿瘤的转移扩散有关。
Applying the immunohistochemical methed, we have studied expressions of oncogene C-ras p21 and of genetic albumin ofnuclear antigen PCNA of the proliferative cell in 120 cases of epitheliomas (60 cases of cystadenocarcinoma. 30 cascs of bordcrline cys-tadenoma and 30 cases of benign cystadenoma). The results of this study show: the pocitive expression rate of C-ras p21 in cystadeno-carinoma of the ovary was 81. 5 % and that of borderline cystadenoma was 60. 6% . while that of benign cystadenoma was only 17. 2 %.A significant difference was found (P< 0.01 ). The positive expression rate of class A (its rate is rnore than 65 % ) of PCNA was88. 25 % in cystadenocarc inoma, and 56. 6% in bord erline cystadenoma. It is show n t hat in the slice s of the ovarian cystadenoma, detec-tion of the positive expression rate of C-ras p21 and cellular proliferation of PCNA has great value in grading and diagnosis for benighand rnalignant ovarian cystadenomas. It also indecates that the cases whose expression of C-ras p21 and PCNA are both poritive haveshorter survival period after operation. C-ras p21 and PCNA expression relates to metastasis of tumors.
关键词
卵巢肿瘤
C-ras
P21
增殖细胞核抗原
免疫组化
Tumors of the ovary Oncogene C-ras p21 Nuclear antigen of the proliferative cell Immunohistochemistry
