摘要
目的:探讨中西医结合疗法对家兔应激性脏器损伤保护作用的机制。方法:将40只大耳白兔随机平分为正常对照组(Ⅰ组),实验对照组(Ⅱ组),西药治疗组(Ⅲ组)和中西医结合组(Ⅳ组)。以浸水方法造成应激模型,造模前Ⅳ组每日2次中药加味丹参饮灌胃,连续5d。造模后Ⅲ组和Ⅳ组注射冬眠合剂,观察各组家兔给药后不同时间血清皮质醇(COR)、血栓素A2(TxA2)、内皮素(ET)以及一氧化氮合酶(NOS)含量的变化;并观察了胃黏膜的病理变化。结果:COR含量,Ⅱ组显著升高,与Ⅰ组比较差异有统计学意义(P<0.01);Ⅲ组以及Ⅳ组含量有所降低,两组间比较差异无统计学意义(P>0.05)。ETNOS,TxA2含量,Ⅳ组明显降低,与Ⅲ组比较差异有统计学意义(P<0.05)。胃黏膜病理变化,Ⅳ组改善明显优于Ⅲ组。结论:冬眠合剂与加味丹参饮对于应激性溃疡的发生具有良好的防治作用。
Objective： To study the protective effects of the integrated traditional Chinese and western medicine on stress organ damage in rabbits. Methods： Forty rabbits were randomly divided into four groups including control group （group Ⅰ）, the model control group （group Ⅱ ）, western medicine group （group Ⅲ）, and the integrated traditional Chinese and western medicine group （group Ⅳ）. The stress organ damage models were made by soaking in water, pour stomach with traditional Chinese medicine JIAWEIDANSHENYIN twice a day for five days in group Ⅳ before model building, and lytic cocktail were injected in group Ⅲ and group Ⅳ after model building. Cortisol （COR）, thromboxane A2 （TxA2）, endothelium （ET）, nitrogen monoxide （NOS） and the pathologic change of the gastric mucosa were observed at different time in each group. Results＇. COR increased significantly in group Ⅱ compared with that in group Ⅰ （P 〈 0.01）, COR decreased in group Ⅲ and group Ⅳ, there was no significant difference between the two groups （P 〉 0.05）. The content of ET, NOS and TxA2 decreased significantly in group Ⅳ compared with that in group Ⅲ （P 〈 0.05）. The pathologic change of the gastric mucosa improved in group Ⅳ compared with that in group Ⅲ. Conclusion： The lytic cocktail and JIAWEIDANSHENYIN have good protective effects on stress ulcer.
出处
《天津医药》
CAS
北大核心
2005年第12期786-788,共3页
Tianjin Medical Journal
关键词
氯丙嗪
异丙嗪
哌替啶
丹参饮
胃溃疡
应激
chlorpromazine promethazine meperidine DANSHEN DRINK stomach ulcer stress
