摘要
目的观察甘草酸二铵治疗烧伤患者肝功能异常的临床效果。方法选择烧伤并发肝功能异常的患者20例,随机分为治疗组和对照组,每组10例。治疗组:常规治疗加静脉滴注甘草酸二铵150mg,加入50g/L葡萄糖溶液中,1次/d,连续14d.对照组仅作常规治疗。于治疗前及治疗后第7、15天抽取两组患者静脉血,检测血清丙氨酸氨基转移酶(ALT)、天冬氨酸氨基转移酶(AST)、γ-谷氨酰转肽酶(GGT)、碱性磷酸酶(ALP)以及前白蛋白(PA)水平,进行对比分析。结果治疗组用药前,ALT、AST、GGT、ALP、PA分别为(168±46)、(104±29)、(162±37)、(149±17)U/L及(310±35)mg/L;治疗后15d,各项指标变化明显(P<0.05),分别为(51±9)、(31±3)、(56±10)、(103±9)U/L及(372±44)mg/L.对照组治疗前后检测结果差异无统计学意义(P>0.05).结论甘草酸二铵降酶作用迅速,对烧伤引起的肝功能异常有明显的治疗作用。
Objective To observe the protective effect of diammonium glycyrrhizinate on hepatic function in burn patients. Methods Twenty burn patients with hepatic dysfunction were enrolled in the study and were randomly divided into 2 groups, i.e. treatment （T, n = 10, with conventional treatment and intravenous infusion of 150 mg diammonium glycyrrhizinate per day for 14 days） , and control （ C, n=10, with conventional treatment） groups. The blood samples in both groups were collected before and 7 and 15 days after the treatment. The serum contents of ALT, AST, GGT, ALP and PA in the blood samples were determined and analyzed comparatively. Results There was obvious difference in the serum contents of ALT, AST, GGT, ALP and PA in the T group before treatment （168 ± 46 U/L, 104 ± 29 U/L, 162 ± 37 U/L,149 ± 17 U/L, 310 ±35 mg/L, respectively ）and 15 days after treatment （51 ±9 U/L, 31 ± 3 U/L, 56 ± 10 U/L,103 ±9 U/L, 372 ±44 mg/L, respectively, P 〈 0.05 ）. There was no difference in these indices in the C group before and after treatment （ P 〉 0.05 ）. Conclusion Diammonium glycyrrhizinate seemed to be beneficial to the management of postburn hepatic dysfunction with obvious rapid depression of hepatic enzymes.
出处
《中华烧伤杂志》
CAS
CSCD
北大核心
2005年第5期353-355,共3页
Chinese Journal of Burns
关键词
烧伤
肝细胞
甘草酸二铵
肝功能试验
Burns
Hepatic cell
Diammonium glycyrrhizinate
Hepatic function test
