摘要
目的了解瘢痕疙瘩组织局部免疫状态的变化。方法SABC法检测24例瘢痕疙瘩和9例正常瘢痕中C5b-9的沉积,直接免疫荧光法检测14例瘢痕疙瘩和8例正常瘢痕中IgG、IgA、IgM、C3的沉积。结果瘢痕疙瘩组织IgA和C5b-9的沉积均显著高于正常瘢痕组织。结论瘢痕疙瘩组织局部存在异常的免疫反应,该反应强于正常瘢痕愈合过程中的生理反应,故推测免疫因素在瘢痕疙瘩发病中具有重要作用。
Objective To study the local immunological changes in keloids. Methods The deposits of C5b-9 in 24 keloid and 9 mature scar specimens were measured by SABC method,and C3 and immunoglobulins in 14 keloid and 8 mature scar specimens were detected by direct immunofluorescent method. Results The deposits of C5b-9 and IgA were stronger in keloids than that of in mature scars. Conclusion There was an abnormal immunological reaction in keloid lesions, which may play an important role in the pathogenesis of keloid.
出处
《中国皮肤性病学杂志》
CAS
北大核心
2005年第12期722-724,共3页
The Chinese Journal of Dermatovenereology
