摘要
通过正交实验确定了氯化亚锡催化合成正丁醛缩1,2-丙二醇的最佳工艺条件为:正丁醛200 mmol, n(正丁醛) ∶ n(1,2-丙二醇)＝1.0 ∶ 1.5,氯化亚锡3 g,环己烷13 mL,回流分水1 h,收率76.35%.并在此条件下合成了多种环缩醛,收率62.18%～81.90%.催化剂可重复使用.
Cyclic acetals were synthesized from n-butyl aldehyde and propylene glycol using SnCl2 as a catalyst. It was determined by orthogonality experiment that the optimal reaction conditions were as follows： n-butyl aldehyde was 200 retool, n（ aldehyde） ： n（glycol） was 1. 0 ：1. 5, SnCl2 was 3 g, the yield was 75.35%. The yields of other cyclic acetals were between 62.18% - 81.90% by fluxing for I h under the optimal reaction conditions. The catalyst can be reused.
出处
《合成化学》
CAS
CSCD
2005年第6期627-629,共3页
Chinese Journal of Synthetic Chemistry
基金
山东省教育厅科研基金资助项目(J99C62)
聊城大学科研基金资助项目(X031013)
关键词
氯化亚锡
环缩醛
催化
合成
stannous chloride
cyclic acctals
catalysis
synthesis
