摘要
目的观察长期服用非那雄胺对前列腺癌血管形成的影响。方法44例T1b^T4期前列腺癌患者,年龄56~86岁,平均72岁。12例诊断前列腺癌前曾用非那雄胺(5 mg/d)3~24个月,平均9个月,设为非那雄胺组,32例未服用非那雄胺者为对照组。组织标本来自前列腺穿刺或经尿道前列腺电切,采用免疫组织化学染色方法观察前列腺癌组织中微血管密度(MVD)及血管内皮生长因子(VEGF)、低氧诱导因子1α(H IF-1α)的表达情况。结果对照组前列腺癌组织中MVD为66.8±17.7,非那雄胺组为48.4±10.8,差异性有统计学意义(P<0.05)。非那雄胺组前列腺癌组织中H IF-1α及VEGF表达阳性率分别为33%、42%,均显著低于对照组的69%、75%(P<0.05)。结论非那雄胺可能通过抑制前列腺癌H IF-1α、VEGF表达而抑制前列腺癌血管形成,这可能是非那雄胺防治前列腺癌的机理之一。
Objective To observe the effect of long-term use of finasteride on angiogenesis of prostate cancer. Methods A total of 44 patients （mean age,72 years; age range, 56 -86 years） with T1b - T4 stage prostate cancer were included. Among them, 12 patients had taken finasteride at 5mg/d for 3 to 24 months （mean,9 months） ; the reemaining 32 patients with no use of finasteride served as controls. The expression of CD34, hypoxia-inducible factor 1 α （ HIF-1 α） , and vascular endothelial growth factor （ VEGF ） were detected by immunohistochemical assay in the tissue samples of prostate cancer and microvessel density （MVD） was analyzed by staining with antibodies to CD34. Results A lower concentration of MVD （48.4 -10.8） in prostate cancer patients treated with finasteride was observed compared with that in the controls （66.8 - 17.7） , showing a significant difference （P 〈 0.05 ）. The positive rates of HIF-1α and VEGF expression were significantly lower in prostate cancer patients treated with finasteride （33% and 42% ） than those in the controls （69% and 75% ,P 〈 0.05 for both）. Conclusions Decreased expression of HIF-1α and VEGF by finasteride may inhibit angiogenesis in prostate cancer. This may be one of the important mechanisms of finasteride in preventing and inhibiting prostate cancer.
出处
《中华泌尿外科杂志》
CAS
CSCD
北大核心
2005年第12期809-811,共3页
Chinese Journal of Urology
关键词
前列腺肿瘤
血管形成
低氧诱导因子
血管内皮生长因子
Prostatic neoplasms
Angiogenesis
Hypoxia-inducible factor
Vascular endothelial growth factor
