摘要
21例健康人和“无症状”胆囊结石病人口服红霉素0.5g,B超分别测定服药前后空腹胆囊容量(FV)及餐后剩余容量(RV).结果示:健康组服药前后FV(ml)分别为11.20±3.36和9.36±2.79,RV(ml)为4.60±2.54和3.16±1.61;胆结石组服药前后FV(ml)分别为20.88±7.14和19.41±7.92,RV(ml)为11.68±5.37和8.08±3.93.服药前后比较差异有显著性(P<0.05～0.01).服药前后胆囊最大排空率(%)健康组分别为59.60±11.93和67.63±18.96(P>0.05);胆结石组分别为44.08±17.91和59.98±13.91(P<0.01).结论认为红霉素可促进正常人和胆囊结石患者的胆囊排空功能,并逆转部分病人的胆囊动力缺陷.
Gallbladder motility disorders are closely related to the formation of gallstones . In our study, we adopted real-time ultrasonography to investigate the effect of oral erythromycin (EM 500 mg) on gallbladder emptying both in the normal subjects and gallstone patients. The results showed: In eleven normal subjects, the fasting gallbladder volume between pre-and post-adminstration was 11.20 ± 3.36 ml vs 9. 63 ± 2. 79 ml(P< 0.01), the residual gallbladder volume was 4. 60 ± 2. 54 ml vs. 3.16 ±1. 61 ml (F< 0.01), the maximal percentage of gallbladder emptying fallowing meal(%) was 59. 6 () 11.93 vs. 67.63 ± 8.96 (P>0.05). In gallstones patients, the fasting gallbladder volume between pre and post - adminstration was 20.88 ± 7.14 ml vs. 19.41 ± 7.92 ml (P <0.05), the residual gallbladder volume was 11. 68±5.37 ml vs. 8.08 ± 3. 93 ml(P< 0.01), the maximal perentage of gallbladder emptying following meal(%) was 44. 08± 17.91 vs. 59.98±13.91(P<0.01). The results illustrated that EM has a prokinetic action on the gallbladder in both normal and gallstone subjects. In clinical practice, EM may be useful in the prevention af cholesteral gallstone formation.
出处
《临床消化病杂志》
1996年第2期54-56,共3页
Chinese Journal of Clinical Gastroenterology
关键词
红霉素
胆囊动力
胆囊结石
Erythromycin Gallbladder motility Gallbladderstone
