摘要
目的:研究海洋真菌多糖YCP对动物抑瘤作用和免疫功能的调节作用,探讨其抗肿瘤作用的机理。方法:采用抗移植性肿瘤实验方法,检测受试药物对荷瘤小鼠的瘤重及体重的影响。以荷瘤小鼠的血清半数溶血值(HC50)及吞噬指数K及吞噬系数α值等为指标,观察药物对免疫功能的影响。结果:与空白对照组相比,YCP(9,3 mg/kg,ivi、p)对小鼠移植瘤肝癌实体型(Heps)、肉瘤180(S180)、Lewis肺癌的肿瘤生长具有明显的抑制作用(P<0.01),且对小鼠的体重无明显的抑制作用。YCP(9,3 mg/kg)可显著提高S180荷瘤小鼠的吞噬指数k和血清半数溶血值(P<0.01,P<0.05)。结论:YCP具有明显的抗肿瘤活性和显著提高S180荷瘤小鼠免疫功能的作用。
AIM： To study the tumor inhibitory effect and immuno-modulation of YCP （a marine fugal polysaccharide） on animals and its mechanism. METHOD： The tumor inhibition of the tested drug was measured by detecting the tumor weights and body weights of the tumor-bearing mice. Its effect on the immunological function was evaluated by detecting HC50, phagocytic index K, phagocytic coefficient α. RESULT： It showed that the tumor growth on mice bearing Heps, Lewis and sarcoma 180 could be significantly inhibited by YCP （9,3 mg/kg, iv） （P 〈 0.01 ） without any significant decrease on the body weights. It also showed that the HC50 and phagocytic index K of S180-bearing mice could be notably increased by YCP （9,3 mg/kg, iv） （ P 〈 0.01, P 〈 0.05）. CONCLUSION： YCP has great anti-tumor activities, and shows immunological enhancement on the S180 bearing mice.
出处
《中国天然药物》
SCIE
CAS
CSCD
2005年第6期396-400,共5页
基金
中国高技术研究发展计划863资助课题(No.2001AA624110,2003AA624110)~~
关键词
海洋真菌多糖
肉瘤180
免疫增强
Marine fugal polysaccharide
Sarcoma 180
Immunological enhancement
