摘要
目的:了解涎腺腺样囊性癌(SACC)中Slit蛋白和其受体Robo的表达并探讨其在肿瘤嗜神经侵袭中的意义。方法:对34例SACC进行组织分型、嗜神经性分组,同时应用免疫组化方法,对SACC中Slit/Robo的表达进行检测。结果:有嗜神经现象、临床复发的SACC病例中Slit/Robo的表达较无嗜神经现象、临床无复发的病例显著升高(P<0.05)。结论:Slit/Robo在不同分组SACC中均存在不同程度的阳性表达。Slit/Robo与SACC的嗜神经性、临床复发具有密切关系。
Objective： To investigate the expression of Slit protein and its receptor Robo protein in human salivary adenoid cystic carcinoma （SACC） and their effects in neural invasive ability. Methods： According to tissue types and neural invasive ability of SACC, the expression of Slit and Robo proteins were detected with immunohistochemical assay from 34 cases. Results： The expression of Slit and Robo proteins in the cases of neurotropism and recurrence significantly increased as compared with that in the cases of non - neural invasion and non - recurrence, （P 〈 0.05）. Conclusion： These results suggested that Slit and Robo proteins were expressed in SACC. Slit and Robo proteins may have relations with neurotropism and recurrence of SACC.
出处
《西北国防医学杂志》
CAS
2005年第6期416-418,F0002,共4页
Medical Journal of National Defending Forces in Northwest China
基金
国家自然科学基金资助项目(30470858)
