摘要
目的:观察黄芩甙对模型小鼠血清ALT、AST和肝组织CAT活力的影响。方法:观察血清ALT、AST和肝组织CAT活力给药前后的变化。结果:黄芩甙大、中、小剂量组以及注射剂组均能显著降低小鼠血清ALT、AST。黄芩苷大、中、小剂量及注射剂组和联苯双酯组动物肝组织匀浆的CAT活力较模型组明显升高。结论:黄芩甙可降低血清ALT、AST和增加肝组织CAT活力可能是其抗ConA肝损伤机理的重要方面。
Objective： Observing the affect of Baicalin to ALT,AST in sera and activity of CAT in liver to model mice. Methods： Except the blank control group were given normal saline by gastrolavage or injection, every other groups were given medicine 0.2ml/mouse/time by gastrolavage in the morning and afternoon on 1^st day and the next afternoon, DDB 150mg/ml, big, middle, small and injection group were given medicine respectively by 200 mg/ml,100 mg/ml,50 mg/ml and 50 mg/ml. Injected in tail vein by ConA 20mg/kg 4- 6 later after the last injected and the mouse were killed. ALT and AST in blood and the activity of CAT in liver tissue were tested. Result ： The values of ALT and AST decreased significantly in groups of big, middle and small dosage of Baicalin and injection（ P 〈 0.01 ）. The activity of CAT was much higher in injection, DDB, and big, middle, small dosage groups of Baiealin than in model group（ P 〈 0.01 ）, the highest in big dosage group and the lowest in DDB. There was no significant difference between middle, small and injection group（ P 〉 0. 05）. Conclusion： Baicalin has better function of reducing ALT, AST than DDB and increasing the activity of CAT in liver tissue, presesuming that it is the important aspect of mechanism of preventing liver lesion by reducing ALT, AST and antioxidation.
出处
《中国中医基础医学杂志》
CAS
CSCD
北大核心
2005年第11期823-825,共3页
JOURNAL OF BASIC CHINESE MEDICINE
