摘要
目的:观察百令胶囊对糖尿病肾病大鼠血压、血糖、24h尿蛋白定量、肾功能及大鼠肾组织病理变化的作用。方法:24只大鼠随机分为对照组、模型组、治疗组,每组各8只。复制糖尿病肾病大鼠模型成功2d后,治疗组每日灌胃百令胶囊(2.5 g/kg),模型组及对照组每日给予等量的饮用水,测定血糖及24 h尿蛋白定量;通过全自动生化分析仪检测血肌酐(Scr)、尿素氮(BUN),并计算内生肌酐清除率(Ccr);通过光镜观察肾脏病理变化。结果:给药12周后,模型组大鼠血糖、平均动脉压、24h尿蛋白定量、Scr、BUN及左肾/体重均明显高于对照组大鼠,而Ccr低于对照组大鼠,均P<0.05,且肾组织出现了较明显的病理损伤;经百令胶囊治疗后,大鼠平均动脉压、24 h尿蛋白定量、Scr、BUN及左肾/体重均明显减低,均P<0.05,血糖减低,Ccr显著增高,P<0.05,肾组织病理损伤明显减轻。结论:百令胶囊对糖尿病肾病大鼠具有肾保护作用。
Objective： To observe the effect of Bailin capsule on blood pressure, blood sugar, urinary protein/24 h, renal function, pathological changes of renal tissue in rats with diabetic nephropathy. Methods： 24 rats were randomly grouped into control,model and treatment,8 rats for each group. Two days after models＇ establishment, Bailin capsule was administrated （2.5 g/kg） by a stomach tube in treatment group,and same amount of water was fed in model and control group. Then we detected the blood sugar, urinary protein/24 h, serum creatinine （Scr）, blood urea nitrogen （BUN）, calculated endogenous creatinine clearance rate （Ccr）, and used optics microscope and electronic microscope to observe the the renal pathological changes. Results：After 12 w,the blood sugar, average arterial pressure, urinary protein/24 h, Scr and BUN in model group were significantly higher compared with control group（respectively, P〈0.05）. However, Ccr in model group was lower than that of control group, and there was obvious renal tissue damage（respectively,P〈0.05）. After treatment of Bailin capsule, the average arterial pressure, urinary protein/24 h, Scr, BUN were reduced, Ccr increased and renal damage eased （respectively, P〈0.05）. Conclusion：Bailin treatment can protect diabetic nephropathy rat models from kidney damage.
出处
《中国中西医结合肾病杂志》
2005年第11期629-632,共4页
Chinese Journal of Integrated Traditional and Western Nephrology
基金
山西省科委基金(No.981034)
关键词
百令胶囊
糖尿病肾病
蛋白尿
病理
Bailin capsule
Diabetic nephropathy
Albuminuria
Pathology
