摘要
为探讨结直肠癌组织中肝素酶表达及其与结直肠癌临床病理参数及血管生成的关系，采用免疫组织化学方法（SP法）检测75例结直肠癌组织及癌旁组织中肝素酶和VEGFD的表达。结果显示，肝素酶在结直肠癌组织中的阳性表达显著高于癌旁组织（P〈0．05）。肝素酶的表达与结直肠癌Dukes分期、淋巴结转移有关（P〈0．05）。VEGFD在结直肠癌组织中表达亦显著高于癌旁组织（P〈0．05），且亦与Dukes分期及淋巴结转移有关（P〈0．05）。肝素酶高表达组VEGFD表达显著高于肝素酶低表达组（P〈0．05）。结果表明，肝素酶在促进结直肠癌的生长、浸润及转移和血管生成中发挥重要作用，可作为结直肠癌预后的参考指标。
The objective of this article is to study the relationship between the expression of heparinase in the colorectal carcinomatous tissues and clinical pathological parameter ＆ angiogenesis on colorectal carcinoma. The expressions of heparinase and vascular endothelial growth factor-D （VEGFD） respectively in colorectal carcinomatous tissues and in adjacent tissues of carcinoma of 75 cases with colorectal carcinoma were measured with immunohistochemical method. Results showed that the positive expression of heparinase in the colorectal carcinomatous tissues was markedly higher than that in the adjacent tissues of carci- noma （P 〈0.05） ,that the expression of heparinase was correlated with Dukes staging and lymphatic metastasis of colorectal carcinoma （P 〈0.05）,that the expression of VEGFD in the colorectal carcinomatous tissues was also higher than that in the adiacent tissues of carcinoma （P 〈0.05） and was also correlated with Dukes staging ＆ lymphatic metastasis （P 〈0.05） ,and that the expression of VEGFD in the heparinase-highly-expressed group was notably higher than that in the heparinase-lower-expressed group （P 〈0.05）. It is suggested that heparinase plays an important role in the promotion of colorectal carcinoma growth ,infiltration, metastasis and angiogenesis ,and that heparinase maybe served as the reference index for prognosis of colorectal carcinoma.
出处
《中国肛肠病杂志》
2005年第10期11-13,共3页
Chinese Journal of Coloproctology
基金
安徽省卫生厅科研基金资助项目（20028076）
