摘要
目的比较肝肾移植受者环孢素(CsA)临床药动学差异。方法采用荧光偏振免疫法测定16例肝肾移植受者服用CsA后不同时间点的血药浓度,计算药动学参数。结果CsA代谢呈二房室开放模型。肝移植受者较肾移植β显著减小,T1/2β、T1/2α延长,t_(max)和达平均稳态血药浓度的时间(tcss)后移。结论CsA药动学参数个体差异大。肝移植受者的CsA分布和消除较肾移植显著减慢,易发生蓄积。
AIM To compare clinical pharmacokinetics of ciclosporin in kidney and liver transplantation recipients. METHODS The whole blood concentrations were measured by fluorescence polarization immunoassay （FPIA） in 16 kidney and liver transplantation recipients after having taken ciclosporin （Neoral） orally and the clinical pharmacokinetic parameters of ciclosporin were calculated. RESULTS Ciclosporin metabolism was a linear two-compartment model with first-order absorption. Comparing steady-state pharmacokinetics of ciclosporin in kidney and liver transplantation recipients, the elimination rate constant （6） in liver transplantation recipients was significantly decreased, T1/2β, T1/2α, tmax and the time of reaching average steady concentration （tcos） in liver transplantation recipients were significantly extended. CONCLUSION Clinical pharmacokinetics of cclosporin are greatly different among patients. Distribution and elimination of ciclosporin in liver transplantation recipients are significantly slower than those in kidney transplantation recipients and it is easy to produce ciclosporin cumulation.
出处
《中国临床药学杂志》
CAS
2005年第6期364-366,共3页
Chinese Journal of Clinical Pharmacy
关键词
肝肾移植
环孢素
药动学
kidney and liver transplantation
ciclosporin
pharmaeokinetics
