摘要
目的观察肺癌肝转移血清可溶性细胞间粘附分子-1(soluble intercellular adhesion molecule-1 sICAM-1)水平,评价检测肺癌肝转移患者(sICAM-1)的临床意义。方法用流式细胞仪(FCMS)对肺癌患者外周血中sICAM-1的水平进行定量测定。结果肺癌组s1CAM-1平均浓度为7.39±6.26,正常对照组s1CAM-1平均浓度为3.37±1.20。肺癌组s1CAM-1水平明显高于对照组,有显著性差异(P<0.01)。肺癌肝转移组s1CAM-1平均浓度为12.10±5.95,无转移癌组s1CAM-1平均浓度为6.36±5.47。肺癌肝转移组s1CAM-1显高于无转移癌组具有显著性差异(P<0.01)。低分化腺癌组略高于高分化腺癌组,二组间差异比较无显著性差异(P>0.05)。腺癌组与鳞癌癌组之间无显著性差异(P>0.05)。结论血清(sICAM-1)水平的检测对评价肺癌患者病情和预后有一定临床意义。
Objective To determine the serum level of soluble ICAM-1 in patients with gastric cancer. Methods FCMS was used to quantify the levels of slCAM-I in peripheral blood of gastric cancer patients. Results slCAM-I were detected in the sea＇um levels of the patients with the lung carcinoma and normal group. Average concentrations of the slCAM-1 was 7.39 ± 6.26 in the lung cancer group, and average concentrations of the slCAM-1 was 3.37 ± 1.20 in the normal group, The level of slCAM-1 was significantly higher in the serum of gastric cancer patients than in the normal control group（ P 〈 0.01 ）. And significantly higher in liver metastasis group than in non-metastasis group（ P 〈 0.01 ）. Conclusion Evaluation of slCAM- 1 concentration may he a valuable parameter for predicting the prognosis and degree of cancer in lung cancer patients.
出处
《中国实验诊断学》
2005年第5期704-705,共2页
Chinese Journal of Laboratory Diagnosis
