摘要
为了明确高血压脑出血的发生机制,研究了脑血管对压力耐受性问题。所制作的模型是以自发性高血压大鼠和京都纯种大鼠为对照,插管至颈内动脉,压力维持在 34· 58 kPa,注射 4～5 ml血液来模仿血压的上升,发现和京都鼠比较,高血压鼠脑出血者较多。脑组织有大小不同的出血,并可渗入蛛网膜下腔。结果提示:这种脑血管的破裂与高血压和老龄化有关(P<0.01),血压变化及老龄化可引起脑血管一系列的退变,这可能是长期高血压导致脑血管壁紧张度增加或痉挛的缘故。
In an attempt to determine the mechanism of cerebral hemorrhage. we studied the pressure endurance of cerebral vessels. We produced a kind of experiment model of cerebral hemorrhage at the pressure 34. 58 kPa by inserting tube into the internal carotid artery and injecting 4-5ml blood into spontaneously hypertensive rats (SHR) and normal Wistar Kyoto Rats (WKR) to imitate the increase of blood pressure. Under light microscope, we found that there was more hemorrhage in the brain of spontaneously hypertensive rats than in the brain of Wistar Kyoto Rats and that fresh hemorrhage occurred in different part of the brain, penetrating into the subarachnoid space. The results showed that cerebral arteries lesion was related to hypertension and aging (P<0. 01). We observed a serial of degeneration brought about by hypertension and aging. It may be the result of prolonged tension of spasm of the arterial wall with longstanding hypertension.
出处
《解剖学杂志》
CAS
CSCD
北大核心
1996年第1期12-16,共5页
Chinese Journal of Anatomy
基金
国家自然科学基金资助课题
