摘要
目的:探讨分泌性中耳炎(SOM)中耳积液(MEE)中P物质(SP)含量与临床的相关性。方法:观察64例(79耳)SOM患者的病程、听力、MEE量、MEE性质及其与MEE中的SP含量的关系。结果:浆液性MEE中SP的浓度比黏液性者明显增高(P<0.01);MEE中的SP含量与MEE量呈正相关(r=0.985,P<0.01),与发病时间呈负相关(r=-0.621 7,P<0.01);听力损失黏液组明显多于浆液组;浆液组MEE中SP含量与听阈呈正相关(r=0.985,P<0.01),黏液组MEE中SP含量与听阈无显著性相关(r=0.241 5,P>0.05)。结论:①SP在SOM的发病中影响了病程的全过程,但在早期起主要作用。②检测SOM MEE中SP含量对于判断MEE的性质,了解病情的发展,指导临床治疗有一定的意义。
Objective：To investigate the correlation of substance P in middle ear effusion and clinical presentation in secretory otitis media. Method： Observation on relation between clinical presentation （the course of disease , the hearing loss, quantity of middle ear effusion or quanlity） and substance P （SP） content of middle ear effusion （MEE） in 64 cases （79 ears） of secretory otitis media （SOM）. Result：SP concentration of MEE in serous group was remarkably higher than that in the mucous group（ P〈0.01）. SP concentration of MEE had positive correlation with the volume（ r = 0. 985, P〈0.01）, and negative correlation with the course of disease （ r = -0.621 7, P〈0.01）. The hearing loss of mucous group was remarkably higher than that of the serous group（ P〈0.01）. SP concentration of MEE in serous group had positive correlation with auditiry threshold（ r = 0. 955 3, P〈0. 01）. SP concentration of MEE in mucous had no correlation with auditiry threshold. Conclusion：SP might play an important role in SOM. The detection of SP content in MEE is of important significace for judging quality of MEE and understanding the course of disease.
出处
《临床耳鼻咽喉科杂志》
CSCD
北大核心
2005年第22期1026-1028,共3页
Journal of Clinical Otorhinolaryngology
关键词
中耳炎
分泌性
P物质
中耳积液
Otitis media, secretory
Substance P
Middle ear effusion
