摘要
目的:观察丙咪嗪治疗间质性膀胱炎的疗效.方法:19例间质性膀胱炎患者,连续服用丙咪嗪25～100 mg/d,3个月.以每日排尿次数、间质性膀胱炎症状评分(ICSI)及问题评分(ICPI)及作为疗效评判标准.治疗前患者ICSI为8～19分(平均12.8±3.7分),ICPI为3～14分(平均8.4±3.1分),排尿次数为10～30次/d(平均18.0±5.8次/d).结果:随访观察3～15个月,平均7.2个月,治疗后3个月13例患者症状明显缓解,有效率68.4%,治疗后1个月、3个月ICSI分别降至(6.4±3.7)、(7.2±3.4)分,ICPI分别降至(3.9±2.5)、(4.3±2.6)分,排尿次数减少至(10.5±3.7)次/d、(11.1±4.2)次/d,均较治疗前明显下降(P＜0.01).结论:丙咪嗪能有效地改善间质性膀胱炎症状及生活质量,可作为间质性膀胱炎一线治疗药物.
Objective： To observe the effects of the tricyclic antidepressant Imipramine on patients with interstitial cystitis （IC）. Methods： 19 patients with interstitial cystitis were treated for 3 months with Imipramine with a dosage from 25 mg to 100 rag. The changes of the OLeary-Sant Interstitial Cystitis Symptom and Problem Index （ICSI, ICPI） and the number of urinations were obtained as the treatment outcome parameter. The ICSI was 8- 19 （average 12.8±3.7）, the ICPI was 3-14 （average 8.4 ± 3. 1）, and the number of urinations was 10-30 times a day （average 18.0 ± 5.8） at baseline. Results： The patients were followed up for 3-15 months （average 7.2 months） after treatment. Thirteen patients （68.4%） gained improvement in symptoms at 3 months. The ICSI decreased to 6.42 3.7 at 1 month, 7.2± 3.4 at 3 months （ P 〈0.01）. The ICPI decreased to 3.9 ±2.5 at 1 month, 4.3±2.6at 3 months （P〈0.01）. The number of urinations decreased to 10.5±3.7 at 1 month, 11.1± 4.2 at 3 months after treatment（ P 〈0.01 ）. Conclusions： Imipramine therapy for 3 months is effective for improving symptoms and quality of life in patients with IC. It can be the first line drug for treating IC.
出处
《临床泌尿外科杂志》
2005年第11期683-684,686,共3页
Journal of Clinical Urology
关键词
膀胱炎
间质性
丙咪嗪
治疗
Cystitis interstitial
Imipramine
Treatment
