摘要
蛋白质内含肽是存在于前体蛋白质中的一段多肽链,靠自我剪切的方式从前体蛋白中释放出来。蛋白质内含肽的发现,不仅在理论上丰富了遗传信息翻译后加工的内容,而且在实践上有重大的生物学意义,特别是在蛋白质纯化方面有着广泛的应用前景。本文就蛋白质内含肽的发现、特征、鉴定、剪接机制及其生物学意义作一概述。
Inteins are internal segment peptides existing in precursor proteins, which could be excised from a precursor protein by self-cleavage.Its discovery not only enriches the content of the process that the gene transfers its information but also has great significance in practice, especially has a wide application prospect in protein purification. In this review, the discovery, characteristics, identification, splicing mechanism of inteins and its biological significance were summarized.
出处
《生物技术通讯》
CAS
2005年第5期552-555,共4页
Letters in Biotechnology
